ID   TXM46_CONAO             Reviewed;          14 AA.
AC   P0CI24;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   02-JUN-2021, entry version 25.
DE   RecName: Full=Conotoxin Ar1446 {ECO:0000303|PubMed:20843009};
DE   AltName: Full=Conotoxin Ar1430 {ECO:0000303|PubMed:20843009};
OS   Conus araneosus (Cobweb cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=101286;
RN   [1]
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, DISULFIDE BONDS,
RP   HYDROXYLATION AT PRO-12, AMIDATION AT CYS-14, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=20843009; DOI=10.1021/ac101867e;
RA   Gupta K., Kumar M., Balaram P.;
RT   "Disulfide bond assignments by mass spectrometry of native natural
RT   peptides: cysteine pairing in disulfide bonded conotoxins.";
RL   Anal. Chem. 82:8313-8319(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20843009}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:20843009}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       2 branch, since 2 residues stand between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   PDB; 2M61; NMR; -; A=1-14.
DR   PDBsum; 2M61; -.
DR   BMRB; P0CI24; -.
DR   SMR; P0CI24; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Direct protein sequencing; Disulfide bond;
KW   Hydroxylation; Secreted; Toxin.
FT   PEPTIDE         1..14
FT                   /note="Conotoxin Ar1446"
FT                   /evidence="ECO:0000269|PubMed:20843009"
FT                   /id="PRO_0000402420"
FT   MOD_RES         12
FT                   /note="4-hydroxyproline; partial"
FT                   /evidence="ECO:0000269|PubMed:20843009"
FT   MOD_RES         14
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000269|PubMed:20843009"
FT   DISULFID        1..14
FT                   /evidence="ECO:0000269|PubMed:20843009,
FT                   ECO:0007744|PDB:2M61"
FT   DISULFID        2..10
FT                   /evidence="ECO:0000269|PubMed:20843009,
FT                   ECO:0007744|PDB:2M61"
FT   DISULFID        6..13
FT                   /evidence="ECO:0000269|PubMed:20843009,
FT                   ECO:0007744|PDB:2M61"
FT   HELIX           5..7
FT                   /evidence="ECO:0007829|PDB:2M61"
SQ   SEQUENCE   14 AA;  1439 MW;  2761FC5A2665F828 CRC64;
     CCRLACGLGC HPCC