ID   TXM4E_DINQU             Reviewed;          69 AA.
AC   P0DSK2;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   03-AUG-2022, entry version 8.
DE   RecName: Full=M-poneratoxin-Dq4e {ECO:0000303|PubMed:28976889};
DE            Short=M-PONTX-Dq4e {ECO:0000303|PubMed:28976889};
DE   AltName: Full=Peptide sDq-3348 {ECO:0000303|PubMed:28976889};
DE   AltName: Full=U-poneritoxin(01)-Dq7a {ECO:0000305};
DE            Short=PONTX(01)-Dq7 (contig 1) {ECO:0000303|PubMed:30214940};
DE            Short=U-PONTX(01)-Dq7a {ECO:0000305};
DE   AltName: Full=contig 9 {ECO:0000303|PubMed:24498135};
DE   Flags: Precursor;
OS   Dinoponera quadriceps (South American ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Dinoponera.
OX   NCBI_TaxID=609295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24498135; DOI=10.1371/journal.pone.0087556;
RA   Torres A.F., Huang C., Chong C.M., Leung S.W., Prieto-da-Silva A.R.,
RA   Havt A., Quinet Y.P., Martins A.M., Lee S.M., Radis-Baptista G.;
RT   "Transcriptome analysis in venom gland of the predatory giant ant
RT   Dinoponera quadriceps: insights into the polypeptide toxin arsenal of
RT   hymenopterans.";
RL   PLoS ONE 9:E87556-E87556(2014).
RN   [2]
RP   FUNCTION, AND SYNTHESIS OF 40-69.
RX   PubMed=28976889; DOI=10.1515/hsz-2017-0198;
RA   Lima D.B., Mello C.P., Bandeira I.C.J., Pessoa Bezerra de Menezes R.R.P.,
RA   Sampaio T.L., Falcao C.B., Morlighem J.R.L., Radis-Baptista G.,
RA   Martins A.M.C.;
RT   "The dinoponeratoxin peptides from the giant ant Dinoponera quadriceps
RT   display in vitro antitrypanosomal activity.";
RL   Biol. Chem. 399:187-196(2018).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=30214940; DOI=10.1126/sciadv.aau4640;
RA   Robinson S.D., Mueller A., Clayton D., Starobova H., Hamilton B.R.,
RA   Payne R.J., Vetter I., King G.F., Undheim E.A.B.;
RT   "A comprehensive portrait of the venom of the giant red bull ant, Myrmecia
RT   gulosa, reveals a hyperdiverse hymenopteran toxin gene family.";
RL   Sci. Adv. 4:EAAU4640-EAAU4640(2018).
CC   -!- FUNCTION: May have antimicrobial properties, like most ant linear
CC       peptides (Probable). In addition, when tested in vitro on the parasite
CC       Trypanosoma cruzi (responsible of the Chagas disease), is able to
CC       moderately reduce the number of the three forms (epimastigote,
CC       trypomastigote and amastigote) by inducing cell death through necrosis
CC       (PubMed:28976889). {ECO:0000269|PubMed:28976889, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24498135}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24498135}.
CC   -!- WEB RESOURCE: Name=National Center for Biotechnology Information
CC       (NCBI);
CC       URL="https://www.ncbi.nlm.nih.gov/nuccore/GANS01000002";
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DR   AlphaFoldDB; P0DSK2; -.
DR   SMR; P0DSK2; -.
DR   Proteomes; UP000515204; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Antimicrobial; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..39
FT                   /evidence="ECO:0000305|PubMed:24498135"
FT                   /id="PRO_0000447087"
FT   PEPTIDE         40..69
FT                   /note="M-poneratoxin-Dq4e"
FT                   /evidence="ECO:0000305|PubMed:24498135"
FT                   /id="PRO_0000447088"
SQ   SEQUENCE   69 AA;  7398 MW;  9AC463F87B4D0A2C CRC64;
     MKLSAFTLAF ALILMMAIMY NMAEAAALAD ADADAEAIAG LKDWWNKHKD KIVKVVKEMG
     KAGINAAGK