ID   TXMG7_MACGS             Reviewed;          77 AA.
AC   Q75WH6;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=U8-hexatoxin-Mg1a;
DE            Short=U8-HXTX-Mg1a;
DE   AltName: Full=Neurotoxin magi-7;
DE   Flags: Precursor;
OS   Macrothele gigas (Japanese funnel web spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Macrothelidae; Macrothele.
OX   NCBI_TaxID=223896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=15246762; DOI=10.1016/j.toxicon.2004.05.012;
RA   Satake H., Villegas E., Oshiro N., Terada K., Shinada T., Corzo G.;
RT   "Rapid and efficient identification of cysteine-rich peptides by random
RT   screening of a venom gland cDNA library from the hexathelid spider
RT   Macrothele gigas.";
RL   Toxicon 44:149-156(2004).
CC   -!- FUNCTION: Intrathorax injection into crickets causes paralysis
CC       prolonged for more than 60 min, followed by recovery.
CC       {ECO:0000269|PubMed:15246762}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- MASS SPECTROMETRY: Mass=3269.6; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15246762};
CC   -!- SIMILARITY: Belongs to the neurotoxin 14 (magi-1) family. 05 (ICK-7)
CC       subfamily.
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DR   EMBL; AB121195; BAD13402.1; -; mRNA.
DR   AlphaFoldDB; Q75WH6; -.
DR   ArachnoServer; AS000387; U8-hexatoxin-Mg1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..43
FT                   /id="PRO_0000285705"
FT   CHAIN           44..77
FT                   /note="U8-hexatoxin-Mg1a"
FT                   /id="PRO_0000285706"
FT   DISULFID        46..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..76
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   77 AA;  8255 MW;  B304C320CC9E1318 CRC64;
     MKVFSFTIGL VVIISLFAFA LAYDEETDLM KKLVEMERAI EQRIICAPEG GPCVVGIGCC
     KGYSCAPGLL GLVGHCQ