TXN4A_DICDI
ID TXN4A_DICDI Reviewed; 160 AA.
AC Q553S5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 4.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Thioredoxin-like protein 4A homolog;
GN Name=txnl4a; ORFNames=DDB_G0275407;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Plays role in pre-mRNA splicing as component of the U5 snRNP
CC and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome
CC assembly, and as component of the precatalytic spliceosome (spliceosome
CC B complex). {ECO:0000250|UniProtKB:P83876}.
CC -!- SUBUNIT: Component of the precatalytic spliceosome (spliceosome B
CC complex). Component of the U5 snRNP complex. Component of the U4/U6-U5
CC tri-snRNP complex. {ECO:0000250|UniProtKB:P83876}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P83876}.
CC -!- SIMILARITY: Belongs to the DIM1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL69769.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AAFI02000013; EAL69769.3; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_643678.5; XM_638586.4.
DR AlphaFoldDB; Q553S5; -.
DR SMR; Q553S5; -.
DR STRING; 44689.DDB0233510; -.
DR PRIDE; Q553S5; -.
DR GeneID; 8619945; -.
DR KEGG; ddi:DDB_G0275407; -.
DR dictyBase; DDB_G0275407; txnl4a.
DR eggNOG; KOG3414; Eukaryota.
DR InParanoid; Q553S5; -.
DR PhylomeDB; Q553S5; -.
DR Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-DDI-72165; mRNA Splicing - Minor Pathway.
DR PRO; PR:Q553S5; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:UniProtKB.
DR GO; GO:0005682; C:U5 snRNP; ISS:dictyBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR CDD; cd02954; DIM1; 1.
DR InterPro; IPR004123; Dim1.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12052; PTHR12052; 1.
DR Pfam; PF02966; DIM1; 1.
DR SMART; SM01410; DIM1; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT CHAIN 1..160
FT /note="Thioredoxin-like protein 4A homolog"
FT /id="PRO_0000331292"
FT REGION 132..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 160 AA; 18662 MW; 1B428F4F4EFE52CE CRC64;
MGGLLIKQLS TEEDRVVVIR FGHDYNPECM KQDDILASIA EKVKNMAVIY VVDITEVPDL
NSMYELYDDC PTMFFYRNKH IMVDLGTGNN NKINWALTNK QDMIDIIETV YKGARKGKGL
VNSPRDFSPQ YKFLKKKKKK KNKKKQKKKI KKIKKKIKNN