TXN4A_MOUSE
ID TXN4A_MOUSE Reviewed; 142 AA.
AC P83877; O14834; Q3TLI3;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Thioredoxin-like protein 4A;
DE AltName: Full=DIM1 protein homolog;
DE AltName: Full=Spliceosomal U5 snRNP-specific 15 kDa protein;
DE AltName: Full=Thioredoxin-like U5 snRNP protein U5-15kD;
GN Name=Txnl4a; Synonyms=Dim1, Txnl4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays role in pre-mRNA splicing as component of the U5 snRNP
CC and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome
CC assembly, and as component of the precatalytic spliceosome (spliceosome
CC B complex). {ECO:0000250|UniProtKB:P83876}.
CC -!- SUBUNIT: Component of the precatalytic spliceosome (spliceosome B
CC complex). Component of the U5 snRNP complex. Component of the U4/U6-U5
CC tri-snRNP complex. The U4/U6-U5 tri-snRNP complex is a building block
CC of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5
CC tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least
CC PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB,
CC SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH,
CC SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7
CC and LSM8. Directly interacts with CD2BP2. Interacts with HNRPF, HNRPH2,
CC NEDD9 and PQBP1. Interacts with ERBB4. {ECO:0000250|UniProtKB:P83876}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P83876}.
CC -!- SIMILARITY: Belongs to the DIM1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK004039; BAB23137.1; -; mRNA.
DR EMBL; AK007331; BAB24966.1; -; mRNA.
DR EMBL; AK148287; BAE28459.1; -; mRNA.
DR EMBL; AK166497; BAE38809.1; -; mRNA.
DR EMBL; BC031634; AAH31634.1; -; mRNA.
DR CCDS; CCDS29365.1; -.
DR RefSeq; NP_079575.1; NM_025299.3.
DR RefSeq; XP_006526550.1; XM_006526487.3.
DR AlphaFoldDB; P83877; -.
DR SMR; P83877; -.
DR BioGRID; 205173; 5.
DR STRING; 10090.ENSMUSP00000115320; -.
DR iPTMnet; P83877; -.
DR PhosphoSitePlus; P83877; -.
DR EPD; P83877; -.
DR MaxQB; P83877; -.
DR PaxDb; P83877; -.
DR PeptideAtlas; P83877; -.
DR PRIDE; P83877; -.
DR ProteomicsDB; 298396; -.
DR Antibodypedia; 23516; 78 antibodies from 20 providers.
DR DNASU; 27366; -.
DR Ensembl; ENSMUST00000145963; ENSMUSP00000115320; ENSMUSG00000057130.
DR GeneID; 27366; -.
DR KEGG; mmu:27366; -.
DR UCSC; uc008fso.1; mouse.
DR CTD; 10907; -.
DR MGI; MGI:1351613; Txnl4a.
DR VEuPathDB; HostDB:ENSMUSG00000057130; -.
DR eggNOG; KOG3414; Eukaryota.
DR GeneTree; ENSGT00390000010779; -.
DR HOGENOM; CLU_117348_0_0_1; -.
DR InParanoid; P83877; -.
DR OMA; DFNEMYE; -.
DR OrthoDB; 1320693at2759; -.
DR PhylomeDB; P83877; -.
DR TreeFam; TF313562; -.
DR Reactome; R-MMU-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-MMU-72165; mRNA Splicing - Minor Pathway.
DR BioGRID-ORCS; 27366; 29 hits in 70 CRISPR screens.
DR ChiTaRS; Txnl4a; mouse.
DR PRO; PR:P83877; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; P83877; protein.
DR Bgee; ENSMUSG00000057130; Expressed in yolk sac and 178 other tissues.
DR ExpressionAtlas; P83877; baseline and differential.
DR Genevisible; P83877; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; ISO:MGI.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:UniProtKB.
DR GO; GO:0005682; C:U5 snRNP; ISO:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR CDD; cd02954; DIM1; 1.
DR InterPro; IPR004123; Dim1.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12052; PTHR12052; 1.
DR Pfam; PF02966; DIM1; 1.
DR PIRSF; PIRSF017199; mRNA_splic_U5; 1.
DR SMART; SM01410; DIM1; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Disulfide bond; Mitosis; mRNA processing;
KW mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome.
FT CHAIN 1..142
FT /note="Thioredoxin-like protein 4A"
FT /id="PRO_0000218288"
FT MOD_RES 132
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P83876"
FT DISULFID 38..79
FT /evidence="ECO:0000250"
SQ SEQUENCE 142 AA; 16786 MW; EDDDAD7ADAEE87F3 CRC64;
MSYMLPHLHN GWQVDQAILS EEDRVVVIRF GHDWDPTCMK MDEVLYSIAE KVKNFAVIYL
VDITEVPDFN KMYELYDPCT VMFFFRNKHI MIDLGTGNNN KINWAMEDKQ EMVDIIETVY
RGARKGRGLV VSPKDYSTKY RY
