TXN4B_HUMAN
ID TXN4B_HUMAN Reviewed; 149 AA.
AC Q9NX01; D3DWS6;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Thioredoxin-like protein 4B;
DE AltName: Full=Dim1-like protein;
GN Name=TXNL4B; Synonyms=DIM2, DLP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15161931; DOI=10.1074/jbc.m402522200;
RA Sun X., Zhang H., Wang D., Ma D., Shen Y., Shang Y.;
RT "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell
RT cycle progression.";
RL J. Biol. Chem. 279:32839-32847(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), AND SUBUNIT.
RX PubMed=16142897; DOI=10.1021/bi050427o;
RA Simeoni F., Arvai A., Bello P., Gondeau C., Hopfner K.-P., Neyroz P.,
RA Heitz F., Tainer J., Divita G.;
RT "Biochemical characterization and crystal structure of a Dim1 family
RT associated protein: Dim2.";
RL Biochemistry 44:11997-12008(2005).
CC -!- FUNCTION: Essential role in pre-mRNA splicing. Required in cell cycle
CC progression for S/G(2) transition. {ECO:0000269|PubMed:15161931}.
CC -!- SUBUNIT: Homodimer. Interacts with the U5-102 kDa protein subunit of
CC the spliceosome. {ECO:0000269|PubMed:16142897}.
CC -!- INTERACTION:
CC Q9NX01; Q9NZN9: AIPL1; NbExp=3; IntAct=EBI-10309345, EBI-6557414;
CC Q9NX01; Q9NXW9: ALKBH4; NbExp=3; IntAct=EBI-10309345, EBI-8637516;
CC Q9NX01; O14503: BHLHE40; NbExp=3; IntAct=EBI-10309345, EBI-711810;
CC Q9NX01; Q86UT8: CENATAC; NbExp=6; IntAct=EBI-10309345, EBI-11028020;
CC Q9NX01; P50221: MEOX1; NbExp=3; IntAct=EBI-10309345, EBI-2864512;
CC Q9NX01; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10309345, EBI-16439278;
CC Q9NX01; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-10309345, EBI-79165;
CC Q9NX01; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-10309345, EBI-742388;
CC Q9NX01; Q96PV4: PNMA5; NbExp=3; IntAct=EBI-10309345, EBI-10171633;
CC Q9NX01; Q04864: REL; NbExp=3; IntAct=EBI-10309345, EBI-307352;
CC Q9NX01; Q15637-4: SF1; NbExp=3; IntAct=EBI-10309345, EBI-12223157;
CC Q9NX01; Q9NZD8: SPG21; NbExp=6; IntAct=EBI-10309345, EBI-742688;
CC Q9NX01; P15884: TCF4; NbExp=4; IntAct=EBI-10309345, EBI-533224;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15161931}.
CC -!- SIMILARITY: Belongs to the DIM1 family. {ECO:0000305}.
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DR EMBL; AY566808; AAS68520.1; -; mRNA.
DR EMBL; AK000518; BAA91224.1; -; mRNA.
DR EMBL; CR457240; CAG33521.1; -; mRNA.
DR EMBL; CH471166; EAW59191.1; -; Genomic_DNA.
DR EMBL; CH471166; EAW59192.1; -; Genomic_DNA.
DR EMBL; BC009646; AAH09646.1; -; mRNA.
DR CCDS; CCDS10906.1; -.
DR RefSeq; NP_001135789.1; NM_001142317.1.
DR RefSeq; NP_001135790.1; NM_001142318.1.
DR RefSeq; NP_060323.1; NM_017853.2.
DR PDB; 1XBS; X-ray; 2.50 A; A=1-149.
DR PDB; 3GIX; X-ray; 1.33 A; A/B=2-149.
DR PDB; 4IN0; X-ray; 1.33 A; A/B=2-149.
DR PDBsum; 1XBS; -.
DR PDBsum; 3GIX; -.
DR PDBsum; 4IN0; -.
DR AlphaFoldDB; Q9NX01; -.
DR SMR; Q9NX01; -.
DR BioGRID; 120295; 37.
DR IntAct; Q9NX01; 13.
DR STRING; 9606.ENSP00000268483; -.
DR iPTMnet; Q9NX01; -.
DR PhosphoSitePlus; Q9NX01; -.
DR BioMuta; TXNL4B; -.
DR DMDM; 51702156; -.
DR EPD; Q9NX01; -.
DR jPOST; Q9NX01; -.
DR MassIVE; Q9NX01; -.
DR MaxQB; Q9NX01; -.
DR PaxDb; Q9NX01; -.
DR PeptideAtlas; Q9NX01; -.
DR PRIDE; Q9NX01; -.
DR ProteomicsDB; 83008; -.
DR Antibodypedia; 30184; 95 antibodies from 22 providers.
DR DNASU; 54957; -.
DR Ensembl; ENST00000268483.8; ENSP00000268483.3; ENSG00000140830.9.
DR Ensembl; ENST00000423037.5; ENSP00000408130.1; ENSG00000140830.9.
DR Ensembl; ENST00000426362.6; ENSP00000392310.2; ENSG00000140830.9.
DR GeneID; 54957; -.
DR KEGG; hsa:54957; -.
DR MANE-Select; ENST00000268483.8; ENSP00000268483.3; NM_017853.3; NP_060323.1.
DR UCSC; uc002fca.4; human.
DR CTD; 54957; -.
DR DisGeNET; 54957; -.
DR GeneCards; TXNL4B; -.
DR HGNC; HGNC:26041; TXNL4B.
DR HPA; ENSG00000140830; Low tissue specificity.
DR MIM; 617722; gene.
DR neXtProt; NX_Q9NX01; -.
DR OpenTargets; ENSG00000140830; -.
DR PharmGKB; PA134944912; -.
DR VEuPathDB; HostDB:ENSG00000140830; -.
DR eggNOG; KOG3414; Eukaryota.
DR GeneTree; ENSGT00390000010779; -.
DR HOGENOM; CLU_117348_1_0_1; -.
DR InParanoid; Q9NX01; -.
DR OMA; AMKGKMI; -.
DR OrthoDB; 1320693at2759; -.
DR PhylomeDB; Q9NX01; -.
DR TreeFam; TF332397; -.
DR PathwayCommons; Q9NX01; -.
DR SignaLink; Q9NX01; -.
DR BioGRID-ORCS; 54957; 590 hits in 1078 CRISPR screens.
DR ChiTaRS; TXNL4B; human.
DR EvolutionaryTrace; Q9NX01; -.
DR GeneWiki; TXNL4B; -.
DR GenomeRNAi; 54957; -.
DR Pharos; Q9NX01; Tbio.
DR PRO; PR:Q9NX01; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9NX01; protein.
DR Bgee; ENSG00000140830; Expressed in medial globus pallidus and 186 other tissues.
DR ExpressionAtlas; Q9NX01; baseline and differential.
DR Genevisible; Q9NX01; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR InterPro; IPR004123; Dim1.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12052; PTHR12052; 1.
DR Pfam; PF02966; DIM1; 1.
DR PIRSF; PIRSF017199; mRNA_splic_U5; 1.
DR SMART; SM01410; DIM1; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome.
FT CHAIN 1..149
FT /note="Thioredoxin-like protein 4B"
FT /id="PRO_0000218289"
FT HELIX 11..20
FT /evidence="ECO:0007829|PDB:4IN0"
FT STRAND 23..31
FT /evidence="ECO:0007829|PDB:4IN0"
FT STRAND 33..35
FT /evidence="ECO:0007829|PDB:1XBS"
FT HELIX 36..49
FT /evidence="ECO:0007829|PDB:4IN0"
FT TURN 50..55
FT /evidence="ECO:0007829|PDB:4IN0"
FT STRAND 56..62
FT /evidence="ECO:0007829|PDB:4IN0"
FT TURN 63..65
FT /evidence="ECO:0007829|PDB:4IN0"
FT HELIX 68..72
FT /evidence="ECO:0007829|PDB:4IN0"
FT STRAND 77..85
FT /evidence="ECO:0007829|PDB:4IN0"
FT STRAND 88..93
FT /evidence="ECO:0007829|PDB:4IN0"
FT STRAND 95..97
FT /evidence="ECO:0007829|PDB:4IN0"
FT STRAND 102..104
FT /evidence="ECO:0007829|PDB:4IN0"
FT HELIX 109..124
FT /evidence="ECO:0007829|PDB:4IN0"
FT STRAND 128..131
FT /evidence="ECO:0007829|PDB:4IN0"
FT HELIX 136..138
FT /evidence="ECO:0007829|PDB:4IN0"
SQ SEQUENCE 149 AA; 17015 MW; 4C63CF5C05425738 CRC64;
MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS DLSKMAAIYL
VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT KFVGSFKTKQ DFIDLIEVIY
RGAMRGKLIV QSPIDPKNIP KYDLLYQDI
