TXN4B_MOUSE
ID TXN4B_MOUSE Reviewed; 149 AA.
AC Q8BUH1; Q52KF0;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Thioredoxin-like protein 4B;
GN Name=Txnl4b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Essential role in pre-mRNA splicing. Required in cell cycle
CC progression for S/G(2) transition (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with the U5-102 kDa protein subunit of
CC the spliceosome (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DIM1 family. {ECO:0000305}.
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DR EMBL; AK085226; BAC39394.1; -; mRNA.
DR EMBL; AC125162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466525; EDL11422.1; -; Genomic_DNA.
DR EMBL; BC094379; AAH94379.1; -; mRNA.
DR EMBL; BC132373; AAI32374.1; -; mRNA.
DR EMBL; BC138333; AAI38334.1; -; mRNA.
DR CCDS; CCDS40469.1; -.
DR RefSeq; NP_783577.2; NM_175646.4.
DR AlphaFoldDB; Q8BUH1; -.
DR SMR; Q8BUH1; -.
DR BioGRID; 231565; 1.
DR STRING; 10090.ENSMUSP00000034159; -.
DR iPTMnet; Q8BUH1; -.
DR PhosphoSitePlus; Q8BUH1; -.
DR EPD; Q8BUH1; -.
DR MaxQB; Q8BUH1; -.
DR PaxDb; Q8BUH1; -.
DR PRIDE; Q8BUH1; -.
DR ProteomicsDB; 298073; -.
DR Antibodypedia; 30184; 95 antibodies from 22 providers.
DR Ensembl; ENSMUST00000034159; ENSMUSP00000034159; ENSMUSG00000031723.
DR Ensembl; ENSMUST00000178445; ENSMUSP00000137524; ENSMUSG00000031723.
DR GeneID; 234723; -.
DR KEGG; mmu:234723; -.
DR UCSC; uc012gkh.1; mouse.
DR CTD; 54957; -.
DR MGI; MGI:2443724; Txnl4b.
DR VEuPathDB; HostDB:ENSMUSG00000031723; -.
DR eggNOG; KOG3414; Eukaryota.
DR GeneTree; ENSGT00390000010779; -.
DR HOGENOM; CLU_117348_1_0_1; -.
DR InParanoid; Q8BUH1; -.
DR OMA; AMKGKMI; -.
DR OrthoDB; 1320693at2759; -.
DR PhylomeDB; Q8BUH1; -.
DR TreeFam; TF332397; -.
DR BioGRID-ORCS; 234723; 28 hits in 106 CRISPR screens.
DR PRO; PR:Q8BUH1; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BUH1; protein.
DR Bgee; ENSMUSG00000031723; Expressed in granulocyte and 212 other tissues.
DR Genevisible; Q8BUH1; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR InterPro; IPR004123; Dim1.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12052; PTHR12052; 1.
DR Pfam; PF02966; DIM1; 1.
DR PIRSF; PIRSF017199; mRNA_splic_U5; 1.
DR SMART; SM01410; DIM1; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; mRNA processing; mRNA splicing; Nucleus; Reference proteome.
FT CHAIN 1..149
FT /note="Thioredoxin-like protein 4B"
FT /id="PRO_0000218290"
FT CONFLICT 25
FT /note="V -> G (in Ref. 1; BAC39394)"
FT /evidence="ECO:0000305"
FT CONFLICT 61
FT /note="V -> G (in Ref. 1; BAC39394)"
FT /evidence="ECO:0000305"
FT CONFLICT 92
FT /note="V -> G (in Ref. 1; BAC39394)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 149 AA; 17020 MW; A9DA3896F5F28758 CRC64;
MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSA DLSKMAAIYL
VDVDHTPVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT KFVGSFKTKQ DFIDLIEVIY
RGAMRGKLIV QSPIDPKNVP KYDLLYQDI
