TXND6_HUMAN
ID TXND6_HUMAN Reviewed; 330 AA.
AC Q86XW9; Q7Z4A8; Q8N1V7;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Thioredoxin domain-containing protein 6 {ECO:0000305};
DE AltName: Full=Thioredoxin-like protein 2;
DE Short=Txl-2;
GN Name=NME9 {ECO:0000312|HGNC:HGNC:21343}; Synonyms=TXL2, TXNDC6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=12569107; DOI=10.1074/jbc.m300369200;
RA Sadek C.M., Jimenez A., Damdimopoulos A.E., Kieselbach T., Nord M.,
RA Gustafsson J.-A., Spyrou G., Davis E.C., Oko R., van der Hoorn F.A.,
RA Miranda-Vizuete A.;
RT "Characterization of human thioredoxin-like 2. A novel microtubule-binding
RT thioredoxin expressed predominantly in the cilia of lung airway epithelium
RT and spermatid manchette and axoneme.";
RL J. Biol. Chem. 278:13133-13142(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-330 (ISOFORM 3).
RA Zhou G., Yu R., Zheng G., Li H., Shen C., Xiao W., Li M., Zhong G., Lin L.,
RA Yang S.;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a regulator of microtubule physiology.
CC {ECO:0000305|PubMed:12569107}.
CC -!- SUBUNIT: Monomer and homodimer.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:A0A1L1SUL6}. Dynein axonemal particle
CC {ECO:0000250|UniProtKB:Q6IRC5}. Note=Associated with microtubules.
CC Detected in cilia of lung epithelium, and associated with the spermatid
CC tail and manchette. {ECO:0000250|UniProtKB:A0A1L1SUL6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q86XW9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86XW9-2; Sequence=VSP_010375, VSP_010377, VSP_010378;
CC Name=3;
CC IsoId=Q86XW9-3; Sequence=VSP_010376, VSP_010378;
CC -!- TISSUE SPECIFICITY: Detected at very low levels in testis, lung and
CC brain. {ECO:0000269|PubMed:12569107}.
CC -!- MISCELLANEOUS: Shows no detectable enzyme activity.
CC -!- SIMILARITY: Belongs to the NDK family. {ECO:0000305}.
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DR EMBL; AF196568; AAG28497.1; -; mRNA.
DR EMBL; AK094830; BAC04430.1; -; mRNA.
DR EMBL; AY336746; AAQ16116.1; -; mRNA.
DR CCDS; CCDS3099.1; -. [Q86XW9-2]
DR CCDS; CCDS87141.1; -. [Q86XW9-3]
DR CCDS; CCDS87142.1; -. [Q86XW9-1]
DR RefSeq; NP_835231.1; NM_178130.3. [Q86XW9-2]
DR AlphaFoldDB; Q86XW9; -.
DR SMR; Q86XW9; -.
DR iPTMnet; Q86XW9; -.
DR PhosphoSitePlus; Q86XW9; -.
DR BioMuta; NME9; -.
DR DMDM; 47606157; -.
DR jPOST; Q86XW9; -.
DR MassIVE; Q86XW9; -.
DR PeptideAtlas; Q86XW9; -.
DR PRIDE; Q86XW9; -.
DR ProteomicsDB; 70335; -. [Q86XW9-1]
DR ProteomicsDB; 70336; -. [Q86XW9-2]
DR ProteomicsDB; 70337; -. [Q86XW9-3]
DR Antibodypedia; 33430; 123 antibodies from 23 providers.
DR DNASU; 347736; -.
DR Ensembl; ENST00000317876.8; ENSP00000321929.4; ENSG00000181322.15. [Q86XW9-2]
DR Ensembl; ENST00000333911.9; ENSP00000335444.3; ENSG00000181322.15. [Q86XW9-1]
DR Ensembl; ENST00000383180.6; ENSP00000372667.2; ENSG00000181322.15. [Q86XW9-2]
DR Ensembl; ENST00000484930.5; ENSP00000419882.1; ENSG00000181322.15. [Q86XW9-3]
DR GeneID; 347736; -.
DR KEGG; hsa:347736; -.
DR MANE-Select; ENST00000333911.9; ENSP00000335444.3; NM_001349018.2; NP_001335947.1.
DR UCSC; uc003ese.1; human. [Q86XW9-1]
DR CTD; 347736; -.
DR DisGeNET; 347736; -.
DR GeneCards; NME9; -.
DR HGNC; HGNC:21343; NME9.
DR HPA; ENSG00000181322; Tissue enhanced (brain, choroid plexus, fallopian tube).
DR MIM; 618584; gene.
DR neXtProt; NX_Q86XW9; -.
DR OpenTargets; ENSG00000181322; -.
DR PharmGKB; PA134909407; -.
DR VEuPathDB; HostDB:ENSG00000181322; -.
DR GeneTree; ENSGT00940000162486; -.
DR HOGENOM; CLU_060216_1_1_1; -.
DR InParanoid; Q86XW9; -.
DR OMA; RTLMGPC; -.
DR OrthoDB; 1473942at2759; -.
DR PhylomeDB; Q86XW9; -.
DR TreeFam; TF106374; -.
DR PathwayCommons; Q86XW9; -.
DR BioGRID-ORCS; 347736; 8 hits in 1068 CRISPR screens.
DR ChiTaRS; NME9; human.
DR GenomeRNAi; 347736; -.
DR Pharos; Q86XW9; Tbio.
DR PRO; PR:Q86XW9; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q86XW9; protein.
DR Bgee; ENSG00000181322; Expressed in right uterine tube and 95 other tissues.
DR ExpressionAtlas; Q86XW9; baseline and differential.
DR Genevisible; Q86XW9; HS.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:InterPro.
DR GO; GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
DR GO; GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
DR GO; GO:0006165; P:nucleoside diphosphate phosphorylation; IEA:InterPro.
DR GO; GO:0006228; P:UTP biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.70.141; -; 1.
DR InterPro; IPR034907; NDK-like_dom.
DR InterPro; IPR036850; NDK-like_dom_sf.
DR InterPro; IPR001564; Nucleoside_diP_kinase.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00334; NDK; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR PRINTS; PR01243; NUCDPKINASE.
DR SMART; SM00562; NDK; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR SUPFAM; SSF54919; SSF54919; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..330
FT /note="Thioredoxin domain-containing protein 6"
FT /id="PRO_0000120161"
FT DOMAIN 11..115
FT /note="Thioredoxin"
FT REGION 157..303
FT /note="NDK"
FT REGION 300..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..22
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_010375"
FT VAR_SEQ 66..128
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_010376"
FT VAR_SEQ 90..128
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_010377"
FT VAR_SEQ 311..330
FT /note="GEAEATAGPTEALCFPEDVD -> ESSTQPRLKITDLD (in isoform 2
FT and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.3"
FT /id="VSP_010378"
FT CONFLICT 214
FT /note="A -> V (in Ref. 3; AAQ16116)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 330 AA; 36856 MW; D6D8072D1B905E6C CRC64;
MGSRKKEIAL QVNISTQELW EEMLSSKGLT VVDVYQGWCG PCKPVVSLFQ KMRIEVGLDL
LHFALAEADR LDVLEKYRGK CEPTFLFYAG GELVAVVRGA NAPLLQKTIL DQLEAEKKVL
AEGRERKVIK DEALSDEDEC VSHGKNNGED EDMVSSERTC TLAIIKPDAV AHGKTDEIIM
KIQEAGFEIL TNEERTMTEA EVRLFYQHKA GEEAFEKLVH HMCSGPSHLL ILTRTEGFED
VVTTWRTVMG PRDPNVARRE QPESLRAQYG TEMPFNAVHG SRDREDADRE LALLFPSLKF
SDKDTEAPQG GEAEATAGPT EALCFPEDVD
