ID   TXND6_MOUSE             Reviewed;         329 AA.
AC   A0A1L1SUL6;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2017, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Thioredoxin domain-containing protein 6 {ECO:0000305};
DE   AltName: Full=Thioredoxin-like protein 2;
DE            Short=Txl-2;
GN   Name=Nme9 {ECO:0000312|MGI:MGI:4359686}; Synonyms=Txl2, Txndc6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000312|Ensembl:ENSMUSP00000150820};
RN   [1] {ECO:0000312|Ensembl:ENSMUSP00000150820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000312|Ensembl:ENSMUSP00000150820};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=12569107; DOI=10.1074/jbc.m300369200;
RA   Sadek C.M., Jimenez A., Damdimopoulos A.E., Kieselbach T., Nord M.,
RA   Gustafsson J.-A., Spyrou G., Davis E.C., Oko R., van der Hoorn F.A.,
RA   Miranda-Vizuete A.;
RT   "Characterization of human thioredoxin-like 2. A novel microtubule-binding
RT   thioredoxin expressed predominantly in the cilia of lung airway epithelium
RT   and spermatid manchette and axoneme.";
RL   J. Biol. Chem. 278:13133-13142(2003).
CC   -!- FUNCTION: May be a regulator of microtubule physiology.
CC       {ECO:0000250|UniProtKB:Q86XW9}.
CC   -!- SUBUNIT: Monomer and homodimer. {ECO:0000250|UniProtKB:Q86XW9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:12569107}. Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:Q6IRC5}. Note=Associated with microtubules.
CC       Detected in cilia of lung epithelium, and associated with the spermatid
CC       tail and manchette. {ECO:0000269|PubMed:12569107}.
CC   -!- TISSUE SPECIFICITY: Expressed in lung airway epithelium (at protein
CC       level). {ECO:0000269|PubMed:12569107}.
CC   -!- SIMILARITY: Belongs to the NDK family. {ECO:0000305}.
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DR   EMBL; AC157994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1L1SUL6; -.
DR   SMR; A0A1L1SUL6; -.
DR   PhosphoSitePlus; A0A1L1SUL6; -.
DR   ProteomicsDB; 358974; -.
DR   Antibodypedia; 33430; 123 antibodies from 23 providers.
DR   Ensembl; ENSMUST00000163199; ENSMUSP00000150820; ENSMUSG00000046242.
DR   MGI; MGI:4359686; Nme9.
DR   VEuPathDB; HostDB:ENSMUSG00000046242; -.
DR   GeneTree; ENSGT00940000162486; -.
DR   OMA; RTLMGPC; -.
DR   ChiTaRS; Nme9; mouse.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; A0A1L1SUL6; protein.
DR   Bgee; ENSMUSG00000046242; Expressed in otolith organ and 29 other tissues.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:InterPro.
DR   GO; GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006165; P:nucleoside diphosphate phosphorylation; IEA:InterPro.
DR   GO; GO:0006228; P:UTP biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.70.141; -; 1.
DR   InterPro; IPR034907; NDK-like_dom.
DR   InterPro; IPR036850; NDK-like_dom_sf.
DR   InterPro; IPR001564; Nucleoside_diP_kinase.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00334; NDK; 1.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   PRINTS; PR01243; NUCDPKINASE.
DR   SMART; SM00562; NDK; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   SUPFAM; SSF54919; SSF54919; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..329
FT                   /note="Thioredoxin domain-containing protein 6"
FT                   /id="PRO_0000452446"
FT   DOMAIN          11..115
FT                   /note="Thioredoxin"
FT   REGION          157..303
FT                   /note="NDK"
FT                   /evidence="ECO:0000250|UniProtKB:Q86XW9"
FT   REGION          303..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  36805 MW;  AF76E422794B1FE3 CRC64;
     MGNRKKEIAL QVNINTQELW EEMLGSKGLT VVDVYQGWCG PCKPMVSLFQ KMRIEVGLDR
     LHFASAEADR LDVLEKYQGK CEPTFLFYTR GELVAVVKGA NPTLLQKTIL QQLEAEKKVP
     AEGGEWRAAT DEELLGALKW PPHRKDGGED GDIASSGKTC TLGIIKPDAV AHGKAEEIIM
     KIQEAGFDIL LKEERTLTEA EMQAFYQHRA REEAFERLVH HMCSGPSHLL ILTKTEGTED
     VVTAWRTFLG PCDPNVARRE HPESLRAQYG TEMPFNAVHG SRDREDANRE LALLFPSFKF
     SDKDKEAPPG AEAQTMVGPV EDPCMSERI