TXND8_RAT
ID TXND8_RAT Reviewed; 127 AA.
AC Q69AB1;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Thioredoxin domain-containing protein 8;
DE AltName: Full=Spermatid-specific thioredoxin-3;
DE Short=Sptrx-3;
GN Name=Txndc8; Synonyms=Sptrx3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=15181017; DOI=10.1074/jbc.m404192200;
RA Jimenez A., Zu W., Rawe V.Y., Pelto-Huikko M., Flickinger C.J.,
RA Sutovsky P., Gustafsson J.-A., Oko R., Miranda-Vizuete A.;
RT "Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-
RT associated thioredoxin, is a specific marker of aberrant spermatogenesis.";
RL J. Biol. Chem. 279:34971-34982(2004).
CC -!- FUNCTION: May be required for post-translational modifications of
CC proteins required for acrosomal biogenesis. May act by reducing
CC disulfide bonds within the sperm (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Testis-specific. Expressed in spermatozoa, sperm
CC tail, elongated and round spermatids. {ECO:0000269|PubMed:15181017}.
CC -!- MISCELLANEOUS: In vasectomized rats, autoantibodies against Txndc8 are
CC present.
CC -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY496270; AAS77224.1; -; mRNA.
DR RefSeq; NP_001004092.1; NM_001004092.2.
DR AlphaFoldDB; Q69AB1; -.
DR SMR; Q69AB1; -.
DR STRING; 10116.ENSRNOP00000041009; -.
DR PaxDb; Q69AB1; -.
DR GeneID; 362525; -.
DR KEGG; rno:362525; -.
DR UCSC; RGD:1303121; rat.
DR CTD; 255220; -.
DR RGD; 1303121; Txndc8.
DR VEuPathDB; HostDB:ENSRNOG00000029073; -.
DR eggNOG; KOG0907; Eukaryota.
DR HOGENOM; CLU_090389_14_6_1; -.
DR InParanoid; Q69AB1; -.
DR OMA; FHAMSLK; -.
DR OrthoDB; 1482186at2759; -.
DR PhylomeDB; Q69AB1; -.
DR TreeFam; TF321403; -.
DR PRO; PR:Q69AB1; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000029073; Expressed in testis and 1 other tissue.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005794; C:Golgi apparatus; IDA:RGD.
DR GO; GO:0036126; C:sperm flagellum; IDA:RGD.
DR GO; GO:0001675; P:acrosome assembly; IEP:RGD.
DR GO; GO:0007283; P:spermatogenesis; IEP:RGD.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Differentiation; Disulfide bond;
KW Golgi apparatus; Redox-active center; Reference proteome; Spermatogenesis.
FT CHAIN 1..127
FT /note="Thioredoxin domain-containing protein 8"
FT /id="PRO_0000120164"
FT DOMAIN 2..127
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT DISULFID 32..35
FT /note="Redox-active"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ SEQUENCE 127 AA; 14569 MW; 081035089954466C CRC64;
MVQKIKSMRE FKELLGAAGN RLVVVEFSAQ WCGPCKMIAP AFQAMSLQYR NVMFAQVDVD
SSQELTEHCS IQVVPTFQMF KHSRKVTPFS RLKRILCCFR SGPGSKKIFE FQGADIEKLE
EKIQELM
