ID   TXND9_CAEEL             Reviewed;         208 AA.
AC   Q11183;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Thioredoxin domain-containing protein 9 {ECO:0000312|WormBase:C05D11.3};
GN   Name=txdc-9 {ECO:0000312|WormBase:C05D11.3};
GN   Synonyms=tag-170 {ECO:0000312|WormBase:C05D11.3};
GN   ORFNames=C05D11.3 {ECO:0000312|WormBase:C05D11.3};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND DISRUPTION PHENOTYPE.
RX   PubMed=15009089; DOI=10.1111/j.1356-9597.2004.00708.x;
RA   Ogawa S., Matsubayashi Y., Nishida E.;
RT   "An evolutionarily conserved gene required for proper microtubule
RT   architecture in Caenorhabditis elegans.";
RL   Genes Cells 9:83-93(2004).
RN   [3]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=25575561; DOI=10.1534/g3.114.015776;
RA   Chen X., Cuadros M.D., Chalfie M.;
RT   "Identification of nonviable genes affecting touch sensitivity in
RT   Caenorhabditis elegans using neuronally enhanced feeding RNA
RT   interference.";
RL   G3 (Bethesda) 5:467-475(2015).
CC   -!- FUNCTION: Required for normal microtubule organization and function
CC       (PubMed:15009089, PubMed:25575561). Regulates tubulin acetylation in
CC       ALM and PLM neurons (PubMed:25575561). {ECO:0000269|PubMed:15009089,
CC       ECO:0000269|PubMed:25575561}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15009089}. Cytoplasm
CC       {ECO:0000269|PubMed:15009089}.
CC   -!- TISSUE SPECIFICITY: Expressed throughout the body with high expression
CC       in the nervous system, including the ventral nerve cord and tail
CC       neurons, and vulva. {ECO:0000269|PubMed:15009089,
CC       ECO:0000269|PubMed:25575561}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from late embryogenesis onwards but
CC       mainly expressed at young adult and adult stages.
CC       {ECO:0000269|PubMed:15009089}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in 60% embryonic
CC       lethality. Surviving 2-cell stage to 64-cell stage embryos display a
CC       disorganized arrangement and do not undergo cell divion. Due to short
CC       and diorganized microtubule arrangement, one cell stage embryos exhibit
CC       nuclear-centrosomal defects, failed cytokinesis, and abnormal
CC       pronuclear activity which include failed male pronucleus migration and
CC       the presence of multiple pronuclei. {ECO:0000269|PubMed:15009089}.
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DR   EMBL; FO080365; CCD63192.1; -; Genomic_DNA.
DR   PIR; G88482; G88482.
DR   RefSeq; NP_498410.1; NM_066009.4.
DR   AlphaFoldDB; Q11183; -.
DR   SMR; Q11183; -.
DR   BioGRID; 47115; 2.
DR   IntAct; Q11183; 1.
DR   STRING; 6239.C05D11.3; -.
DR   EPD; Q11183; -.
DR   PaxDb; Q11183; -.
DR   PeptideAtlas; Q11183; -.
DR   EnsemblMetazoa; C05D11.3.1; C05D11.3.1; WBGene00006515.
DR   GeneID; 182257; -.
DR   KEGG; cel:CELE_C05D11.3; -.
DR   UCSC; C05D11.3; c. elegans.
DR   CTD; 182257; -.
DR   WormBase; C05D11.3; CE01133; WBGene00006515; txdc-9.
DR   eggNOG; KOG1672; Eukaryota.
DR   GeneTree; ENSGT00390000015645; -.
DR   HOGENOM; CLU_072378_2_0_1; -.
DR   InParanoid; Q11183; -.
DR   OMA; YDNEEDW; -.
DR   OrthoDB; 1444223at2759; -.
DR   PhylomeDB; Q11183; -.
DR   PRO; PR:Q11183; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00006515; Expressed in embryo and 11 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:WormBase.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..208
FT                   /note="Thioredoxin domain-containing protein 9"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000120170"
FT   DOMAIN          68..179
FT                   /note="Thioredoxin"
SQ   SEQUENCE   208 AA;  24379 MW;  F8F1BC0DFEC9A431 CRC64;
     MAANIQQQFG EQLLRAAQVV EEQIDQEMNK LENLEEDDLE VIRRQRMEQM KKAQKDRIEM
     LSHGHGKYEE VADEKEFFEA TKKSDKVVCL FYLPGNFRCK IVDKHFEILA RKHVGTRFIH
     VNAEKVHFLT TRLNIRVIPS IAIVVKQQTV DYIRGFDELG GKDEFTTETM ENRLARSEVL
     TVEKKHTAPA KKKIIRSGVE EYDNEEDW