ID   C71A2_SOLME             Reviewed;         505 AA.
AC   P37118;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Cytochrome P450 71A2;
DE            EC=1.14.-.-;
DE   AltName: Full=CYPLXXIA2;
DE   AltName: Full=Cytochrome P-450EG4;
GN   Name=CYP71A2; Synonyms=CYPEG4;
OS   Solanum melongena (Eggplant) (Aubergine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4111;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Sinsadoharanasu; TISSUE=Hypocotyl;
RX   PubMed=8365486; DOI=10.1016/0014-5793(93)80266-w;
RA   Umemoto N., Kobayashi O., Ishizaki-Nishizawa O., Toguri T.;
RT   "cDNAs sequences encoding cytochrome P450 (CYP71 family) from eggplant
RT   seedlings.";
RL   FEBS Lett. 330:169-173(1993).
CC   -!- FUNCTION: May have a role in maturation, such as during flavor
CC       formation or other metabolite production specific to aging tissues.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}. Membrane; Single-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; D14990; BAA03635.1; -; mRNA.
DR   EMBL; X71654; CAA50645.1; -; mRNA.
DR   PIR; S36806; S36806.
DR   AlphaFoldDB; P37118; -.
DR   SMR; P37118; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..505
FT                   /note="Cytochrome P450 71A2"
FT                   /id="PRO_0000052057"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         448
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   505 AA;  57092 MW;  0890DD39E1473584 CRC64;
     MDVPCPWYSL LIPLFVFIFL LIHHCFFTTS KKQNMLLLPS PRKLPIIGNL HQLGSLPHRS
     LHKLSQKYGP VMLLHFGSKP VIVASSVDAA RDIMKTHDVV WASRPKSSIV DRLSYGSKDV
     GFSPFGEYWR RAKSITVLHL LSNTRVQSYR NVRAEETANM IGKIRQGCDS SVINLGEHLC
     SLTNNIISRV ALGRTYDEKE SGIEHIIEQF VELLGIFNVG DYIPRLEWVN KFTGLDAKVK
     KVAKELDMFL EIVIEEHIIR KKKEEYTSTG EAKDFVDVLL EIQNGNETDF PLQRDSLKAI
     LLDSFAAGTD TTFATLDWTM AELLRQPRAL KTLQDEVRGL AQGKSEITED DLKNMQYLRA
     VIKESLRLHP TQESLLVPRE SMEDVNLLGY YHIPARTQAI INAWAIGRDP LSWENPEEYQ
     PERFLNSDAD VKGLNFKLLP FGAGRRGCPG SSFAIAVIEL ALARLVHKFD FALPEGIKPE
     DLDMTETIGI TTRRKLPLLV VATPC