ID   TXP3_BRAAI              Reviewed;          89 AA.
AC   P0DMD9; V5RFM6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Omega-theraphotoxin-Ba1c;
DE            Short=Omega-TRTX-Ba1c;
DE   AltName: Full=Venom peptide Ba3 {ECO:0000303|PubMed:24349574};
DE   Flags: Precursor;
OS   Brachypelma albiceps (Mexican golden redrump tarantula) (Brachypelma
OS   ruhnaui).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Brachypelma.
OX   NCBI_TaxID=503929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Venom gland;
RX   PubMed=24349574; DOI=10.1371/journal.pone.0084404;
RA   Ardisson-Araujo D.M., Morgado Fda S., Schwartz E.F., Corzo G.,
RA   Ribeiro B.M.;
RT   "A new theraphosid spider toxin causes early insect cell death by necrosis
RT   when expressed in vitro during recombinant baculovirus infection.";
RL   PLoS ONE 8:E84404-E84404(2013).
CC   -!- FUNCTION: Inhibits voltage-gated calcium channels (Cav) in rat
CC       cerebellar granule cells (By similarity). Has insecticidal activity (By
CC       similarity). {ECO:0000250|UniProtKB:P0DL81,
CC       ECO:0000250|UniProtKB:P85497}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 06 (TXP1)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; KF638632; AHB33348.1; -; mRNA.
DR   AlphaFoldDB; P0DMD9; -.
DR   SMR; P0DMD9; -.
DR   ArachnoServer; AS001892; omega-theraphotoxin-Ba1c.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012625; Toxin_20.
DR   Pfam; PF08089; Toxin_20; 1.
DR   PROSITE; PS60022; HWTX_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium channel impairing toxin; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin;
KW   Voltage-gated calcium channel impairing toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..50
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000425966"
FT   PEPTIDE         51..89
FT                   /note="Omega-theraphotoxin-Ba1c"
FT                   /id="PRO_0000425967"
FT   DISULFID        54..75
FT                   /evidence="ECO:0000250|UniProtKB:P0DL80"
FT   DISULFID        58..81
FT                   /evidence="ECO:0000250|UniProtKB:P0DL80"
FT   DISULFID        67..86
FT                   /evidence="ECO:0000250|UniProtKB:P0DL80"
SQ   SEQUENCE   89 AA;  9745 MW;  A6B94174EB4E69A3 CRC64;
     MRSLTLAAVL ACSLLLVFHT SAAEEHEAQE GYLMNPGDTD TALATVDDER ILECVFSCDI
     EKEGKPCKPK GEKKCTGGWK CKIKLCLKI