ID   TXPH_PYETR              Reviewed;         289 AA.
AC   Q07338;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Toxin tox21A;
DE   AltName: Full=Insect-selective neurotoxin TxP-I homolog;
DE   Flags: Precursor;
OS   Pyemotes tritici (Straw itch mite) (Acarus tritici).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Heterostigmata;
OC   Pyemotoidea; Pyemotidae; Pyemotes.
OX   NCBI_TaxID=6950;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8470135; DOI=10.1016/0041-0101(93)90149-d;
RA   Tomalski M.D., Hutchinson K., Todd J., Miller L.K.;
RT   "Identification and characterization of tox21A: a mite cDNA encoding a
RT   paralytic neurotoxin related to TxP-I.";
RL   Toxicon 31:319-326(1993).
CC   -!- FUNCTION: Has contracting-paralyzing activity in insect larvae.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Posterior glands which appear to be connected with
CC       the stylet through a series of ducts.
CC   -!- PTM: Contains several disulfide bonds.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; S58065; AAB26160.1; -; mRNA.
DR   EMBL; L09272; AAA29801.1; -; mRNA.
DR   PIR; A45369; A45369.
DR   AlphaFoldDB; Q07338; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016329; Neurotoxin_TxP-I.
DR   PIRSF; PIRSF001883; Neurotoxin_TxP-I; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..14
FT                   /evidence="ECO:0000255"
FT   PROPEP          15..27
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000035172"
FT   CHAIN           28..289
FT                   /note="Toxin tox21A"
FT                   /id="PRO_0000035173"
FT   REGION          270..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   289 AA;  32732 MW;  476534ED1B84CB5B CRC64;
     MNLYFLFFIS TILAAKPFNS FNKTSLIDEG VDNDDDIVSK RAVVIDYCDT RHPNNLCKKY
     FEIDSYWNDD TDCFTNIGCK VYGGFDIIGG KAPKIGTVCR LKKGKNKFGY CNSKGNCVER
     DFIESFGVSI KIKGISHRGD DEPACPLYEN TWINYGKCNE PYHCGTNYGL FYANKRKLNY
     FPDNGQKCNS KYEIYGVCYL GRCHGTGNFS NGEVFSEFGT IFKDVEIVTL SDGKNSSKRG
     KHKNLHGSKV FDSNGIYDID PKNWKIEDDD KDITVHENAG DPKSDSRRC