ID   C71A4_SOLME             Reviewed;         507 AA.
AC   P37117;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Cytochrome P450 71A4;
DE            EC=1.14.-.-;
DE   AltName: Full=CYPLXXIA4;
DE   AltName: Full=Cytochrome P-450EG2;
GN   Name=CYP71A4; Synonyms=CYPEG2;
OS   Solanum melongena (Eggplant) (Aubergine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4111;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Sinsadoharanasu; TISSUE=Hypocotyl;
RX   PubMed=8365486; DOI=10.1016/0014-5793(93)80266-w;
RA   Umemoto N., Kobayashi O., Ishizaki-Nishizawa O., Toguri T.;
RT   "cDNAs sequences encoding cytochrome P450 (CYP71 family) from eggplant
RT   seedlings.";
RL   FEBS Lett. 330:169-173(1993).
CC   -!- FUNCTION: May have a role in maturation, such as during flavor
CC       formation or other metabolite production specific to aging tissues.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; X70981; CAA50312.1; -; mRNA.
DR   PIR; S36805; S36805.
DR   AlphaFoldDB; P37117; -.
DR   SMR; P37117; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..507
FT                   /note="Cytochrome P450 71A4"
FT                   /id="PRO_0000052059"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         448
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   507 AA;  57638 MW;  AF28204EDB05D49F CRC64;
     MDVPCLWYSL LILLLLFIFL LIHHCFTTSK TQNMFLPPSP RKLPIIGNLH QLGSHPHRSL
     RKLSQKYGPV MLLHLGSKPV IVASSVDAAR DILKTHDHVW ATRPKYSIAD SLLYGSKDVG
     FSPFGEYWWQ VRSIVVLHLL SNKRVQSYRD VREEETANMI EKIRQGCDAS VINLGEHLCF
     LTNNITSRVA LGRTYDERES GIDAKDILEQ FLQLLDTFNV GDYIPWLKWV NKITGLDTKV
     EKIAKKLDTF LDSVIEEHII RNKKEEYAIT DEAKDFVDVL LEIQNGKETD FPLQRDSLKA
     ILLDAFAAGT DTIYTNLDWT MADVLRQPRA MKTLQNEVRG LAQGKSEITE DDLKNMQYLR
     AVIKESLRLH PPNSLLVPRE SMEDVKLLGY YHIPARTQAL INVWAIGRDP LSWENPEEFC
     PERFLNNDID MKGLKFELLP FGSGRRGCPG SSFAIAVIEL ALARLVHKFN FALPKGTKPE
     DLDMTECTGI ATRRKSPLPV VATPFSG