TXTP_CAEEL
ID TXTP_CAEEL Reviewed; 312 AA.
AC P34519;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Putative tricarboxylate transport protein, mitochondrial;
DE AltName: Full=Citrate transport protein;
DE Short=CTP;
DE Flags: Precursor;
GN ORFNames=K11H3.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Transport of citrate across inner mitochondrial membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; Z22180; CAA80178.1; -; Genomic_DNA.
DR PIR; H88567; H88567.
DR RefSeq; NP_499187.1; NM_066786.4.
DR AlphaFoldDB; P34519; -.
DR SMR; P34519; -.
DR BioGRID; 41592; 3.
DR STRING; 6239.K11H3.3; -.
DR EPD; P34519; -.
DR PaxDb; P34519; -.
DR PeptideAtlas; P34519; -.
DR EnsemblMetazoa; K11H3.3.1; K11H3.3.1; WBGene00010780.
DR GeneID; 176398; -.
DR KEGG; cel:CELE_K11H3.3; -.
DR UCSC; K11H3.3; c. elegans.
DR CTD; 176398; -.
DR WormBase; K11H3.3; CE00474; WBGene00010780; -.
DR eggNOG; KOG0756; Eukaryota.
DR GeneTree; ENSGT00940000172429; -.
DR HOGENOM; CLU_015166_5_1_1; -.
DR InParanoid; P34519; -.
DR OMA; YEWYKQL; -.
DR OrthoDB; 1523221at2759; -.
DR PhylomeDB; P34519; -.
DR Reactome; R-CEL-70263; Gluconeogenesis.
DR Reactome; R-CEL-75105; Fatty acyl-CoA biosynthesis.
DR PRO; PR:P34519; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00010780; Expressed in adult organism and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0071913; F:citrate secondary active transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006843; P:mitochondrial citrate transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transit peptide; Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..312
FT /note="Putative tricarboxylate transport protein,
FT mitochondrial"
FT /id="PRO_0000019264"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 23..111
FT /note="Solcar 1"
FT REPEAT 122..208
FT /note="Solcar 2"
FT REPEAT 218..303
FT /note="Solcar 3"
SQ SEQUENCE 312 AA; 34219 MW; C2829734CF387B71 CRC64;
MSGIQPVPGA KPLSMWQQYG PSEKTVRGIV IGGITGGIEI CITFPTEYVK TQLQLDERSA
TPKFRGPIDC VKQTVNGHGF FGLYRGLSVL LYGSIPKSSF RFGTFEYLKS QAADERGNLS
PVMRLLCGLG AGLSEAVFAV TPMETVKVKF IHDQGLAQPK YKGFVHGVGC IVKAEGLGGI
YKGVTATMAK QGSNQAIRFF VMETLKDWYR GGDNTQPISK PIVGLMGAVA GAASVYGNTP
IDVVKTRMQG LEAKKYKNTL DCAMQIWKKE GFFAFYKGTV PRLSRVCLDV GITFMIYDSI
IEFLDVYWKK QQ
