TXTP_YEAST
ID TXTP_YEAST Reviewed; 299 AA.
AC P38152; D6VQT6; Q02507;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 3.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Tricarboxylate transport protein;
DE AltName: Full=Citrate transport protein;
DE Short=CTP;
GN Name=CTP1; OrderedLocusNames=YBR291C; ORFNames=YBR2039;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ATCC 200358 / YNN 295;
RX PubMed=7876161; DOI=10.1074/jbc.270.8.4108;
RA Kaplan R.S., Mayor J.A., Gremse D.A., Wood D.O.;
RT "High level expression and characterization of the mitochondrial citrate
RT transport protein from the yeast Saccharomyces cerevisiae.";
RL J. Biol. Chem. 270:4108-4114(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091861; DOI=10.1002/yea.320100007;
RA Holmstroem K., Brandt T., Kallesoe T.;
RT "The sequence of a 32,420 bp segment located on the right arm of chromosome
RT II from Saccharomyces cerevisiae.";
RL Yeast 10:S47-S62(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- FUNCTION: Transport of citrate across inner mitochondrial membrane.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; U17503; AAC48984.1; -; mRNA.
DR EMBL; X76053; CAA53655.1; -; Genomic_DNA.
DR EMBL; Z36160; CAA85256.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07406.1; -; Genomic_DNA.
DR PIR; S44554; S44554.
DR RefSeq; NP_009850.1; NM_001178639.1.
DR AlphaFoldDB; P38152; -.
DR SMR; P38152; -.
DR BioGRID; 32985; 180.
DR DIP; DIP-5645N; -.
DR IntAct; P38152; 12.
DR MINT; P38152; -.
DR STRING; 4932.YBR291C; -.
DR TCDB; 2.A.29.7.3; the mitochondrial carrier (mc) family.
DR iPTMnet; P38152; -.
DR MaxQB; P38152; -.
DR PaxDb; P38152; -.
DR PRIDE; P38152; -.
DR EnsemblFungi; YBR291C_mRNA; YBR291C; YBR291C.
DR GeneID; 852594; -.
DR KEGG; sce:YBR291C; -.
DR SGD; S000000495; CTP1.
DR VEuPathDB; FungiDB:YBR291C; -.
DR eggNOG; KOG0756; Eukaryota.
DR GeneTree; ENSGT00940000172429; -.
DR HOGENOM; CLU_015166_5_1_1; -.
DR InParanoid; P38152; -.
DR OMA; CPAFIVG; -.
DR BioCyc; YEAST:G3O-29210-MON; -.
DR Reactome; R-SCE-70263; Gluconeogenesis.
DR Reactome; R-SCE-75105; Fatty acyl-CoA biosynthesis.
DR PRO; PR:P38152; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38152; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0071913; F:citrate secondary active transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005371; F:tricarboxylate secondary active transmembrane transporter activity; IDA:SGD.
DR GO; GO:0006843; P:mitochondrial citrate transmembrane transport; IDA:SGD.
DR GO; GO:0055085; P:transmembrane transport; IDA:SGD.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..299
FT /note="Tricarboxylate transport protein"
FT /id="PRO_0000090653"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..193
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 10..97
FT /note="Solcar 1"
FT REPEAT 109..199
FT /note="Solcar 2"
FT REPEAT 212..297
FT /note="Solcar 3"
FT CONFLICT 97
FT /note="M -> L (in Ref. 1; AAC48984)"
FT /evidence="ECO:0000305"
FT CONFLICT 101
FT /note="S -> R (in Ref. 1; AAC48984)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 299 AA; 32173 MW; E0A9749704BA1405 CRC64;
MSSKATKSDV DPLHSFLAGS LAGAAEACIT YPFEFAKTRL QLIDKASKAS RNPLVLIYKT
AKTQGIGSIY VGCPAFIIGN TAKAGIRFLG FDTIKDMLRD SETGELSGTR GVIAGLGAGL
LESVAAVTPF EAIKTALIDD KQSATPKYHN NGRGVVRNYS SLVRDKGFSG LYRGVLPVSM
RQAANQAVRL GCYNKIKTLI QDYTDSPKDK PLSSGLTFLV GAFSGIVTVY STMPLDTVKT
RMQSLDSTKY SSTMNCFATI FKEEGLKTFW KGATPRLGRL VLSGGIVFTI YEKVLVMLA
