ID   TXVE1_MACLB             Reviewed;          13 AA.
AC   P0CJ33;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   26-FEB-2020, entry version 14.
DE   RecName: Full=Snake venom vascular endothelial growth factor toxin IC1 {ECO:0000303|PubMed:19695228};
DE            Short=svVEGF;
DE   AltName: Full=Increasing capillary-1 {ECO:0000303|PubMed:19695228};
DE   AltName: Full=VEGF-F {ECO:0000250|UniProtKB:P0DL42};
DE   Flags: Fragment;
OS   Macrovipera lebetina (Levantine viper) (Vipera lebetina).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Viperinae; Macrovipera.
OX   NCBI_TaxID=8709;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, INTERACTION WITH KDR; NRP1 AND NRP2,
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=19695228; DOI=10.1016/j.bbrc.2009.08.068;
RA   Aloui Z., Hoos S., Geretti E., Kharmachi H., Haumont P.Y., Mejdoub H.,
RA   Klagsbrun M., England P., Gasmi A.;
RT   "Novel svVEGF isoforms from Macrovipera lebetina venom interact with
RT   neuropilins.";
RL   Biochem. Biophys. Res. Commun. 389:10-15(2009).
CC   -!- FUNCTION: Induces capillary permeability through VEGF receptor
CC       (KDR/VEGFR-2) signaling. May also induce angiogenesis.
CC       {ECO:0000269|PubMed:19695228}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked (By similarity). Interacts with
CC       high affinity with KDR/VEGFR-2, and with a lower affinity with
CC       neuropilin-1 (NRP1) and neuropilin-2 (NRP2). {ECO:0000250,
CC       ECO:0000269|PubMed:19695228}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19695228}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family. Snake venom
CC       VEGF subfamily. {ECO:0000305}.
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DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Growth factor;
KW   Pyrrolidone carboxylic acid; Secreted; Toxin.
FT   CHAIN           1..>13
FT                   /note="Snake venom vascular endothelial growth factor toxin
FT                   IC1"
FT                   /id="PRO_0000406346"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid (Glu)"
FT                   /evidence="ECO:0000250|UniProtKB:P0DL42"
FT   NON_TER         13
SQ   SEQUENCE   13 AA;  1605 MW;  3B4B13D3D053CB07 CRC64;
     EVRPFPEVYE RIA