ID   TXVE_BOTER              Reviewed;         146 AA.
AC   Q6J936;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Snake venom vascular endothelial growth factor toxin;
DE            Short=svVEGF;
DE   AltName: Full=VEGF-F {ECO:0000250|UniProtKB:P0DL42};
DE   Flags: Precursor;
OS   Bothrops erythromelas (Caatinga lance head).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX   NCBI_TaxID=44710;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=15450933; DOI=10.1016/j.toxicon.2004.07.013;
RA   Junqueira-de-Azevedo I.L.M., da Silva M.B., Chudzinski-Tavassi A.M.,
RA   Ho P.L.;
RT   "Identification and cloning of snake venom vascular endothelial growth
RT   factor (svVEGF) from Bothrops erythromelas pitviper.";
RL   Toxicon 44:571-575(2004).
CC   -!- FUNCTION: Induces capillary permeability and angiogenesis through VEGF
CC       receptor (KDR/VEGFR-2) signaling. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family. Snake venom
CC       VEGF subfamily. {ECO:0000305}.
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DR   EMBL; AY569310; AAT11786.1; -; mRNA.
DR   AlphaFoldDB; Q6J936; -.
DR   SMR; Q6J936; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00135; PDGF; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR023581; PD_growth_factor_CS.
DR   InterPro; IPR000072; PDGF/VEGF_dom.
DR   Pfam; PF00341; PDGF; 1.
DR   SMART; SM00141; PDGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00249; PDGF_1; 1.
DR   PROSITE; PS50278; PDGF_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Growth factor; Pyrrolidone carboxylic acid; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..146
FT                   /note="Snake venom vascular endothelial growth factor
FT                   toxin"
FT                   /id="PRO_0000023424"
FT   REGION          118..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         25
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P83942"
FT   DISULFID        38..80
FT                   /evidence="ECO:0000250"
FT   DISULFID        63
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        69..115
FT                   /evidence="ECO:0000250"
FT   DISULFID        72
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        73..117
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   146 AA;  16364 MW;  B8514B335D90C5C6 CRC64;
     MAAYLLAVAI LFCIQGWPLG TVQGQVMPFM EVYRHSVCQP RETLVSILEE YPGEIAHIFR
     PSCVTALRCG GCCTDESLEC TATGKRSVGR EIMRLSPHKG TSEKEVMQFT EHTDCECRPR
     SASGVNSRKH KRNPEEGEQR AKFPFV