TXVE_BOTIN
ID TXVE_BOTIN Reviewed; 146 AA.
AC Q90X24;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Snake venom vascular endothelial growth factor toxin;
DE Short=svVEGF;
DE AltName: Full=VEGF-F {ECO:0000250|UniProtKB:P0DL42};
DE Flags: Precursor;
OS Bothrops insularis (Golden lancehead) (Lachesis insularis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX NCBI_TaxID=8723;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom gland;
RX PubMed=11517227; DOI=10.1074/jbc.m106531200;
RA Junqueira de Azevedo I.L.M., Farsky S.H.P., Oliveira M.L.S., Ho P.L.;
RT "Molecular cloning and expression of a functional snake venom vascular
RT endothelium growth factor (VEGF) from the Bothrops insularis pit viper. A
RT new member of the VEGF family of proteins.";
RL J. Biol. Chem. 276:39836-39842(2001).
CC -!- FUNCTION: Induces capillary permeability through VEGF (VEGFR)
CC signaling. May also induce angiogenesis. {ECO:0000269|PubMed:11517227}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250|UniProtKB:P15692,
CC ECO:0000269|PubMed:11517227}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11517227}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family. Snake venom
CC VEGF subfamily. {ECO:0000305}.
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DR EMBL; AY033151; AAK52102.1; -; mRNA.
DR AlphaFoldDB; Q90X24; -.
DR SMR; Q90X24; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Growth factor; Pyrrolidone carboxylic acid; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..24
FT /evidence="ECO:0000255, ECO:0000312|EMBL:AAK52102.1"
FT CHAIN 25..146
FT /note="Snake venom vascular endothelial growth factor
FT toxin"
FT /id="PRO_0000023423"
FT REGION 119..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 25
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P83942"
FT DISULFID 38..80
FT /evidence="ECO:0000250|UniProtKB:P15692"
FT DISULFID 63
FT /note="Interchain"
FT /evidence="ECO:0000250|UniProtKB:P15692"
FT DISULFID 69..115
FT /evidence="ECO:0000250|UniProtKB:P15692"
FT DISULFID 72
FT /note="Interchain"
FT /evidence="ECO:0000250|UniProtKB:P15692"
FT DISULFID 73..117
FT /evidence="ECO:0000250|UniProtKB:P15692"
SQ SEQUENCE 146 AA; 16356 MW; 066FC5100CF46331 CRC64;
MAAYLLAVAI LFCIQGWPLG TVQGQVMPFM EVYRHSVCQT RETLVSILEE HPDEVSHIFR
PSCVTALRCG GCCTDESLKC TATGKRSVGR EIMRVDPHKG TSKTEVMQFT EHTDCECRPR
SASGVNSRKH KRNPEEGEPR AKFPFV
