ID   TXVE_CROAT              Reviewed;         144 AA.
AC   C0K3N3;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Snake venom vascular endothelial growth factor toxin cratrin {ECO:0000303|PubMed:19208624};
DE            Short=svVEGF;
DE   AltName: Full=VEGF-F {ECO:0000250|UniProtKB:P0DL42};
DE   Flags: Precursor;
OS   Crotalus atrox (Western diamondback rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=8730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=19208624; DOI=10.1074/jbc.m809071200;
RA   Yamazaki Y., Matsunaga Y., Tokunaga Y., Obayashi S., Saito M., Morita T.;
RT   "Snake venom vascular endothelial growth factors (VEGF-Fs) exclusively vary
RT   their structures and functions among species.";
RL   J. Biol. Chem. 284:9885-9891(2009).
CC   -!- FUNCTION: Induces capillary permeability and angiogenesis through VEGF
CC       receptor (KDR/VEGFR-2) signaling. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family. Snake venom
CC       VEGF subfamily. {ECO:0000305}.
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DR   EMBL; FJ554637; ACN22040.1; -; mRNA.
DR   AlphaFoldDB; C0K3N3; -.
DR   SMR; C0K3N3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00135; PDGF; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR023581; PD_growth_factor_CS.
DR   InterPro; IPR000072; PDGF/VEGF_dom.
DR   Pfam; PF00341; PDGF; 1.
DR   SMART; SM00141; PDGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00249; PDGF_1; 1.
DR   PROSITE; PS50278; PDGF_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Growth factor; Pyrrolidone carboxylic acid; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..144
FT                   /note="Snake venom vascular endothelial growth factor toxin
FT                   cratrin"
FT                   /id="PRO_5000452062"
FT   REGION          119..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..137
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         25
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P83942"
FT   DISULFID        38..80
FT                   /evidence="ECO:0000250"
FT   DISULFID        63
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        69..115
FT                   /evidence="ECO:0000250"
FT   DISULFID        72
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        73..117
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   144 AA;  16126 MW;  49F5197653C92A6E CRC64;
     MAVYLLAVAI LFCIQGWPSG TVQGQAMSFM EVYERSVCQT REMLVSILDE YPSEVAHLFR
     PSCVTVLRCG GCCTDESLTC TATGKRSVGR EIMRVDPRKG TSKIEVMQFT EHTECECRPR
     STVNNGKRKK NPKEGEPRAK FPLV