TXVE_PROFL
ID TXVE_PROFL Reviewed; 146 AA.
AC P67862; C0K3N6; Q68BI5; T2HPC7;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Snake venom vascular endothelial growth factor toxin;
DE Short=svVEGF;
DE AltName: Full=VEGF-F {ECO:0000303|PubMed:19208624};
DE Flags: Precursor;
OS Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops.
OX NCBI_TaxID=88087;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, INTERACTION WITH FLT1 AND
RP KDR, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom gland;
RX PubMed=15328352; DOI=10.1074/jbc.m403687200;
RA Takahashi H., Hattori S., Iwamatsu A., Takizawa H., Shibuya M.;
RT "A novel snake venom vascular endothelial growth factor (VEGF)
RT predominantly induces vascular permeability through preferential signaling
RT via VEGF receptor-1.";
RL J. Biol. Chem. 279:46304-46314(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=19208624; DOI=10.1074/jbc.m809071200;
RA Yamazaki Y., Matsunaga Y., Tokunaga Y., Obayashi S., Saito M., Morita T.;
RT "Snake venom vascular endothelial growth factors (VEGF-Fs) exclusively vary
RT their structures and functions among species.";
RL J. Biol. Chem. 284:9885-9891(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=24224955; DOI=10.1186/1471-2164-14-790;
RA Aird S.D., Watanabe Y., Villar-Briones A., Roy M.C., Terada K.,
RA Mikheyev A.S.;
RT "Quantitative high-throughput profiling of snake venom gland transcriptomes
RT and proteomes (Ovophis okinavensis and Protobothrops flavoviridis).";
RL BMC Genomics 14:790-790(2013).
CC -!- FUNCTION: Strongly increases vascular permeability, and weakly
CC stimulates angiogenesis. Interacts with human VEGF receptor-1 (FLT1)
CC with a high affinity, whereas it binds to human VEGF receptor-2 (KDR)
CC with a low affinity. Stimulates autophosphorylation of VEGF receptor-1
CC (VEGFR-1/FLT1), and VEGF receptor-2 (VEGFR-2/KDR).
CC {ECO:0000269|PubMed:15328352}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with human VEGF
CC receptor-1 (FLT1) with a high affinity, whereas it binds to human VEGF
CC receptor-2 (KDR) with a low affinity. Does not bind VEGF receptor-3
CC (FLT4). {ECO:0000269|PubMed:15328352}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15328352}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- MISCELLANEOUS: IC(50) to VEGF receptor-1 is 30 ng/ml and IC(50) to VEGF
CC receptor-2 is 254 ng/ml.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family. Snake venom
CC VEGF subfamily. {ECO:0000305}.
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DR EMBL; AB154417; BAD38844.1; -; mRNA.
DR EMBL; FJ554640; ACN22043.1; -; Genomic_DNA.
DR EMBL; AB848141; BAN82012.1; -; mRNA.
DR EMBL; AB985235; BAP39960.1; -; mRNA.
DR AlphaFoldDB; P67862; -.
DR SMR; P67862; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Growth factor; Pyrrolidone carboxylic acid; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..146
FT /note="Snake venom vascular endothelial growth factor
FT toxin"
FT /id="PRO_0000023426"
FT REGION 118..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 25
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P83942"
FT DISULFID 38..80
FT /evidence="ECO:0000250"
FT DISULFID 63
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 69..115
FT /evidence="ECO:0000250"
FT DISULFID 72
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 73..117
FT /evidence="ECO:0000250"
SQ SEQUENCE 146 AA; 16152 MW; 8CB18BBD80973228 CRC64;
MAAYLLAVAI LFCIQGWPSG TVQGQVMPFM EVYSRSACQT RETLVPILKE YPDEVSHLFK
PSCVPVLRCG GCCSDESLTC TATGKHSVGR EIMRVDPHKG TSKMEVMQFK EHTACECRPR
SPGDVNNGKD KRNPEEGGPR ARFPFV
