ID   TY01_PHYSA              Reviewed;          61 AA.
AC   C0HJF6;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   22-JAN-2014, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Tryptophyllin-1 {ECO:0000303|PubMed:23518460};
DE            Short=PsT-1 {ECO:0000303|PubMed:23518460};
DE   Flags: Precursor;
OS   Phyllomedusa sauvagei (Sauvage's leaf frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=8395;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 54-61, SYNTHESIS, FUNCTION,
RP   AND MASS SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:23518460};
RX   PubMed=23518460; DOI=10.1016/j.regpep.2013.03.017;
RA   Wang R., Chen T., Zhou M., Wang L., Shaw C.;
RT   "PsT-1: a new tryptophyllin peptide from the skin secretion of Waxy Monkey
RT   Leaf Frog, Phyllomedusa sauvagei.";
RL   Regul. Pept. 184:14-21(2013).
CC   -!- FUNCTION: The synthetic peptide inhibits bradykinin-induced relaxation
CC       of rat tail artery smooth muscle, and also has anti-proliferative
CC       effects on the human prostate cancer cell lines LNCaP, PC3 and DU145.
CC       {ECO:0000269|PubMed:23518460}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23518460}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=919.48; Mass_error=0.919; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:23518460};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Tryptophillin subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; C0HJF6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..53
FT                   /evidence="ECO:0000269|PubMed:23518460"
FT                   /id="PRO_0000424895"
FT   PEPTIDE         54..61
FT                   /note="Tryptophyllin-1"
FT                   /evidence="ECO:0000269|PubMed:23518460"
FT                   /id="PRO_0000424896"
FT   REGION          24..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   61 AA;  7162 MW;  F42FE046DD10BC49 CRC64;
     MDILKKSLFL ALFLGLVSIS FCDEEKRQDD DESNESEEKK EIHEEGSQEE RREKPPPWVP
     V