ID   TY13_BOMVA              Reviewed;          14 AA.
AC   P84215;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   09-NOV-2004, sequence version 1.
DT   17-JUN-2020, entry version 27.
DE   RecName: Full=Tryptophyllin-13;
OS   Bombina variegata (Yellow-bellied toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Bombinatoridae; Bombina.
OX   NCBI_TaxID=8348;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:15134346};
RX   PubMed=15134346; DOI=10.1515/bc.2004.027;
RA   Marenah L., Flatt P.R., Orr D.F., McClean S., Shaw C., Abdel-Wahab Y.H.;
RT   "Skin secretion of the toad Bombina variegata contains multiple insulin-
RT   releasing peptides including bombesin and entirely novel insulinotropic
RT   structures.";
RL   Biol. Chem. 385:315-321(2004).
CC   -!- FUNCTION: Stimulates insulin release. {ECO:0000269|PubMed:15134346}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15134346}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:15134346}.
CC   -!- MASS SPECTROMETRY: Mass=1650.5; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:15134346};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Tryptophillin subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; TAS:UniProtKB.
DR   GO; GO:0006952; P:defense response; TAS:UniProtKB.
DR   GO; GO:0050796; P:regulation of insulin secretion; IDA:UniProtKB.
DR   InterPro; IPR013266; Tryptophillin.
DR   Pfam; PF08248; Tryp_FSAP; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Tryptophyllin-13"
FT                   /id="PRO_0000043843"
SQ   SEQUENCE   14 AA;  1651 MW;  23C4809C33A0DC77 CRC64;
     GKPFYPPPIY PEDM