C71AI_ARATH
ID C71AI_ARATH Reviewed; 497 AA.
AC Q9SAB6;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Cytochrome P450 71A18;
DE EC=1.14.-.-;
GN Name=CYP71A18; OrderedLocusNames=At1g11610; ORFNames=F25C20.24;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9SAB6-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD30262.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007296; AAD30262.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28760.1; -; Genomic_DNA.
DR PIR; E86249; E86249.
DR RefSeq; NP_172627.2; NM_101034.3. [Q9SAB6-1]
DR AlphaFoldDB; Q9SAB6; -.
DR SMR; Q9SAB6; -.
DR STRING; 3702.AT1G11610.2; -.
DR PaxDb; Q9SAB6; -.
DR PRIDE; Q9SAB6; -.
DR ProteomicsDB; 240485; -. [Q9SAB6-1]
DR EnsemblPlants; AT1G11610.1; AT1G11610.1; AT1G11610. [Q9SAB6-1]
DR GeneID; 837705; -.
DR Gramene; AT1G11610.1; AT1G11610.1; AT1G11610. [Q9SAB6-1]
DR KEGG; ath:AT1G11610; -.
DR Araport; AT1G11610; -.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_001570_4_0_1; -.
DR InParanoid; Q9SAB6; -.
DR OMA; MESARIQ; -.
DR PhylomeDB; Q9SAB6; -.
DR PRO; PR:Q9SAB6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SAB6; baseline and differential.
DR Genevisible; Q9SAB6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; SSF48264; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Heme; Iron; Membrane; Metal-binding; Monooxygenase;
KW Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..497
FT /note="Cytochrome P450 71A18"
FT /id="PRO_0000052068"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 439
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 497 AA; 56277 MW; C55F37F8C28944C5 CRC64;
MEMTLMVSLC LTTLLTLLLL KKFLKRTAKK VNLPPSPWRI PVIGNLHQLS LHPHRSLHSL
SLRYGPLMLL HFGRVPILVV SSSEAAHEIL KTHDLKFANR PKSKAVHGLM NGGRDVVFGP
YGEYWRQMKS VCILNLLTNK MVASFEKVRE EEVNAMMEKL EKASCSSSAE NLSELFVTLT
SDVTSRVSLG KKYWEDETAG GLKKRVRQIM ELLREFPIGD YVPALAWIDR INGFNSKIVE
VSRAYSDLME KVVQEHLEAG EHKADFVNIL LSIEKEKNNG FKVQRNDIKF MILDMFIGGI
STSSTLLEWI MTELIRNPEC MKKLQNEIRS TIRPHGSYIK EKEVENMRYL KAVIKEVFRV
HPPLPLILPR LLTEDVKVKG YDIAAGTEVL INAWSIHRDP AIWGPDAEEF KPERHLDSTL
DYHGQDLKYI PFGSGRRICP GINLAMGLVE VTLANLVGRF DWSVDPGPNG DQPDLAEDFG
LDVCRKNPLI AFPSSVA
