ID   TYB12_LATJA             Reviewed;          44 AA.
AC   P33248;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Thymosin beta-12;
OS   Lateolabrax japonicus (Japanese sea perch) (Japanese sea bass).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Pempheriformes; Lateolabracidae; Lateolabrax.
OX   NCBI_TaxID=8164;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-44, AND ACETYLATION AT SER-2.
RC   TISSUE=Liver;
RX   PubMed=1731637; DOI=10.1016/0003-9861(92)90361-y;
RA   Low T.L.K., Liu D.T.-W., Jou J.-H.;
RT   "Primary structure of thymosin beta 12, a new member of the beta-thymosin
RT   family isolated from perch liver.";
RL   Arch. Biochem. Biophys. 293:32-39(1992).
CC   -!- FUNCTION: Plays an important role in the organization of the
CC       cytoskeleton. Binds to and sequesters actin monomers (G actin) and
CC       therefore inhibits actin polymerization (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the thymosin beta family. {ECO:0000305}.
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DR   PIR; S21694; S21694.
DR   AlphaFoldDB; P33248; -.
DR   SMR; P33248; -.
DR   iPTMnet; P33248; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003785; F:actin monomer binding; IEA:InterPro.
DR   GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR   Gene3D; 1.20.5.520; -; 1.
DR   InterPro; IPR001152; Beta-thymosin.
DR   InterPro; IPR038386; Beta-thymosin_sf.
DR   PANTHER; PTHR12021; PTHR12021; 1.
DR   Pfam; PF01290; Thymosin; 1.
DR   PIRSF; PIRSF001828; Thymosin_beta; 1.
DR   SMART; SM00152; THY; 1.
DR   PROSITE; PS00500; THYMOSIN_B4; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Actin-binding; Cytoplasm; Cytoskeleton;
KW   Direct protein sequencing.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:1731637"
FT   CHAIN           2..44
FT                   /note="Thymosin beta-12"
FT                   /id="PRO_0000045938"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000269|PubMed:1731637"
SQ   SEQUENCE   44 AA;  4910 MW;  E7E4A371C62CEFDA CRC64;
     MSDKPDISEV TSFDKTKLKK TETQEKNPLP SKETIEQEKA AATS