ID   TYB4Y_HUMAN             Reviewed;          44 AA.
AC   O14604; Q0VDA2;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 176.
DE   RecName: Full=Thymosin beta-4, Y-chromosomal;
GN   Name=TMSB4Y; Synonyms=TB4Y;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9381176; DOI=10.1126/science.278.5338.675;
RA   Lahn B.T., Page D.C.;
RT   "Functional coherence of the human Y chromosome.";
RL   Science 278:675-680(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12815422; DOI=10.1038/nature01722;
RA   Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA   Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA   Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA   Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA   McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA   Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA   Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT   "The male-specific region of the human Y chromosome is a mosaic of discrete
RT   sequence classes.";
RL   Nature 423:825-837(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hypothalamus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays an important role in the organization of the
CC       cytoskeleton. Binds to and sequesters actin monomers (G actin) and
CC       therefore inhibits actin polymerization (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       O14604; Q9NYB0: TERF2IP; NbExp=2; IntAct=EBI-751196, EBI-750109;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the thymosin beta family. {ECO:0000305}.
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DR   EMBL; AF000989; AAC51836.1; -; mRNA.
DR   EMBL; AC006371; AAD54509.1; -; Genomic_DNA.
DR   EMBL; BC022482; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC119763; AAI19764.1; -; mRNA.
DR   EMBL; BC119764; AAI19765.1; -; mRNA.
DR   CCDS; CCDS14786.1; -.
DR   RefSeq; NP_004193.1; NM_004202.2.
DR   AlphaFoldDB; O14604; -.
DR   SMR; O14604; -.
DR   BioGRID; 114543; 35.
DR   IntAct; O14604; 4.
DR   iPTMnet; O14604; -.
DR   PhosphoSitePlus; O14604; -.
DR   BioMuta; TMSB4Y; -.
DR   jPOST; O14604; -.
DR   MassIVE; O14604; -.
DR   MaxQB; O14604; -.
DR   PaxDb; O14604; -.
DR   PeptideAtlas; O14604; -.
DR   PRIDE; O14604; -.
DR   ProteomicsDB; 48110; -.
DR   Antibodypedia; 58313; 40 antibodies from 10 providers.
DR   DNASU; 9087; -.
DR   Ensembl; ENST00000284856.4; ENSP00000284856.3; ENSG00000154620.6.
DR   GeneID; 9087; -.
DR   KEGG; hsa:9087; -.
DR   MANE-Select; ENST00000284856.4; ENSP00000284856.3; NM_004202.3; NP_004193.1.
DR   UCSC; uc004ftb.4; human.
DR   CTD; 9087; -.
DR   DisGeNET; 9087; -.
DR   GeneCards; TMSB4Y; -.
DR   HGNC; HGNC:11882; TMSB4Y.
DR   HPA; ENSG00000154620; Tissue enhanced (intestine).
DR   MIM; 400017; gene.
DR   neXtProt; NX_O14604; -.
DR   OpenTargets; ENSG00000154620; -.
DR   PharmGKB; PA36582; -.
DR   VEuPathDB; HostDB:ENSG00000154620; -.
DR   GeneTree; ENSGT00940000154433; -.
DR   HOGENOM; CLU_208046_0_0_1; -.
DR   InParanoid; O14604; -.
DR   OrthoDB; 1632292at2759; -.
DR   PhylomeDB; O14604; -.
DR   PathwayCommons; O14604; -.
DR   SignaLink; O14604; -.
DR   BioGRID-ORCS; 9087; 37 hits in 636 CRISPR screens.
DR   GeneWiki; Thymosin_beta-4,_Y-chromosomal; -.
DR   GenomeRNAi; 9087; -.
DR   Pharos; O14604; Tdark.
DR   PRO; PR:O14604; -.
DR   Proteomes; UP000005640; Chromosome Y.
DR   Bgee; ENSG00000154620; Expressed in corpus callosum and 80 other tissues.
DR   Genevisible; O14604; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR   GO; GO:0008064; P:regulation of actin polymerization or depolymerization; TAS:ProtInc.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR   Gene3D; 1.20.5.520; -; 1.
DR   InterPro; IPR001152; Beta-thymosin.
DR   InterPro; IPR038386; Beta-thymosin_sf.
DR   PANTHER; PTHR12021; PTHR12021; 1.
DR   Pfam; PF01290; Thymosin; 1.
DR   PIRSF; PIRSF001828; Thymosin_beta; 1.
DR   SMART; SM00152; THY; 1.
DR   PROSITE; PS00500; THYMOSIN_B4; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..44
FT                   /note="Thymosin beta-4, Y-chromosomal"
FT                   /id="PRO_0000045921"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   44 AA;  5013 MW;  7B336158483A9BE2 CRC64;
     MSDKPGMAEI EKFDKSKLKK TETQEKNPLS SKETIEQERQ AGES