ID   TYB_DANRE               Reviewed;          45 AA.
AC   Q9W7M8;
DT   11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Thymosin beta;
GN   Name=tmsb;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10068630; DOI=10.1242/dev.126.7.1365;
RA   Roth L.W., Bormann P., Bonnet A., Reinhard E.;
RT   "Beta-thymosin is required for axonal tract formation in developing
RT   zebrafish brain.";
RL   Development 126:1365-1374(1999).
CC   -!- FUNCTION: Plays an important role in the organization of the
CC       cytoskeleton. Binds to and sequesters actin monomers (G actin) and
CC       therefore inhibits actin polymerization (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the thymosin beta family. {ECO:0000305}.
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DR   EMBL; AF006831; AAD42010.1; -; mRNA.
DR   RefSeq; NP_991144.1; NM_205581.1.
DR   AlphaFoldDB; Q9W7M8; -.
DR   SMR; Q9W7M8; -.
DR   STRING; 7955.ENSDARP00000071665; -.
DR   PaxDb; Q9W7M8; -.
DR   Ensembl; ENSDART00000077197; ENSDARP00000071665; ENSDARG00000054911.
DR   Ensembl; ENSDART00000185643; ENSDARP00000147634; ENSDARG00000054911.
DR   GeneID; 402820; -.
DR   KEGG; dre:402820; -.
DR   CTD; 402820; -.
DR   ZFIN; ZDB-GENE-050307-5; tmsb.
DR   eggNOG; KOG4794; Eukaryota.
DR   GeneTree; ENSGT00980000198599; -.
DR   HOGENOM; CLU_208046_0_0_1; -.
DR   InParanoid; Q9W7M8; -.
DR   OrthoDB; 1632292at2759; -.
DR   PhylomeDB; Q9W7M8; -.
DR   PRO; PR:Q9W7M8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000054911; Expressed in larva and 19 other tissues.
DR   ExpressionAtlas; Q9W7M8; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR   GO; GO:0043152; P:induction of bacterial agglutination; IDA:ZFIN.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0106014; P:regulation of inflammatory response to wounding; IDA:ZFIN.
DR   GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR   Gene3D; 1.20.5.520; -; 1.
DR   InterPro; IPR001152; Beta-thymosin.
DR   InterPro; IPR038386; Beta-thymosin_sf.
DR   PANTHER; PTHR12021; PTHR12021; 1.
DR   Pfam; PF01290; Thymosin; 1.
DR   PIRSF; PIRSF001828; Thymosin_beta; 1.
DR   SMART; SM00152; THY; 1.
DR   PROSITE; PS00500; THYMOSIN_B4; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..45
FT                   /note="Thymosin beta"
FT                   /id="PRO_0000045934"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   45 AA;  5208 MW;  91F56A20339980E3 CRC64;
     MADKPNMTEI TSFDKTKLRK TETQEKNPLP TKETIEQERQ GESTP