ID   TYDC1_PAPSO             Reviewed;         518 AA.
AC   P54768;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Tyrosine/DOPA decarboxylase 1;
DE   Includes:
DE     RecName: Full=DOPA decarboxylase;
DE              Short=DDC;
DE              EC=4.1.1.28;
DE   Includes:
DE     RecName: Full=Tyrosine decarboxylase;
DE              EC=4.1.1.25;
GN   Name=TYDC1;
OS   Papaver somniferum (Opium poppy).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC   Papaver.
OX   NCBI_TaxID=3469;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Marianne;
RX   PubMed=7929401; DOI=10.1016/s0021-9258(18)47073-1;
RA   Facchini P.J., de Luca V.;
RT   "Differential and tissue-specific expression of a gene family for
RT   tyrosine/dopa decarboxylase in opium poppy.";
RL   J. Biol. Chem. 269:26684-26690(1994).
CC   -!- FUNCTION: Marginally higher substrate specificity for L-DOPA over L-
CC       tyrosine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-tyrosine = CO2 + tyramine; Xref=Rhea:RHEA:14345,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:58315,
CC         ChEBI:CHEBI:327995; EC=4.1.1.25;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-dopa = CO2 + dopamine; Xref=Rhea:RHEA:12272,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57504,
CC         ChEBI:CHEBI:59905; EC=4.1.1.28;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-hydroxy-L-tryptophan + H(+) = CO2 + serotonin;
CC         Xref=Rhea:RHEA:18533, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:58266, ChEBI:CHEBI:350546; EC=4.1.1.28;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in the roots.
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U08597; AAA62346.1; -; Genomic_DNA.
DR   PIR; A55066; A55066.
DR   AlphaFoldDB; P54768; -.
DR   SMR; P54768; -.
DR   BRENDA; 4.1.1.25; 4515.
DR   GO; GO:0036467; F:5-hydroxy-L-tryptophan decarboxylase activity; IEA:RHEA.
DR   GO; GO:0036468; F:L-dopa decarboxylase activity; IEA:RHEA.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0004837; F:tyrosine decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR010977; Aromatic_deC.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   InterPro; IPR021115; Pyridoxal-P_BS.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   PRINTS; PR00800; YHDCRBOXLASE.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   PROSITE; PS00392; DDC_GAD_HDC_YDC; 1.
PE   2: Evidence at transcript level;
KW   Decarboxylase; Lyase; Pyridoxal phosphate.
FT   CHAIN           1..518
FT                   /note="Tyrosine/DOPA decarboxylase 1"
FT                   /id="PRO_0000146999"
FT   MOD_RES         321
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   518 AA;  57020 MW;  E63A53B45ECF2702 CRC64;
     MGSLPANNFE SMSLCSQNPL DPDEFRRQGH MIIDFLADYY KNVEKYPVRT QVDPGYLKKR
     LPESAPYNPE SIETILEDVT NDIIPGLTHW QSPNYFAYFP SSGSIAGFLG EMLSTGFNVV
     GFNWMSSPAA TELESIVMNW LGQMLTLPKS FLFSSDGSSG GGGVLQGTTC EAILCTLTAA
     RDKMLNKIGR ENINKLVVYA SDQTLSALQK AAQIAGINPK NFLAIATSKA TNFGLSPNSL
     QSTILADIES GLVPLFLCAT VGTTSSTAVD PIGPLCAVAK LHGIWVHIDA AYAGSACICP
     EFRHFIDGVE DADSFSLNAH KWFFTTLDCC CLWVKDSDSL VKALSTSPEY LKNKATDSKQ
     VIDYKDWQIA LSRRFRSMKL WLVLRSYGIA NLRTFLRSHV KMAKHFQGLI GMDNRFEIVV
     PRTFAMVCFR LKPAAIFRKK IVEDDHIEAQ TNEVNAKLLE SVNASGKIYM THAVVGGVYM
     IRFAVGATLT EERHVTGAWK VVQEHTDAIL GALGEDVC