ID   TYDC1_PETCR             Reviewed;         432 AA.
AC   Q06085;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Tyrosine decarboxylase 1;
DE            EC=4.1.1.25;
DE   AltName: Full=ELI5;
DE   Flags: Fragment;
GN   Name=TYRDC-1;
OS   Petroselinum crispum (Parsley) (Petroselinum hortense).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Apiales; Apiaceae; Apioideae; apioid superclade;
OC   Apieae; Petroselinum.
OX   NCBI_TaxID=4043;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8420986; DOI=10.1016/s0021-9258(18)53980-6;
RA   Kawalleck P., Keller H., Hahlbrock K., Scheel D., Somssich I.E.;
RT   "A pathogen-responsive gene of parsley encodes tyrosine decarboxylase.";
RL   J. Biol. Chem. 268:2189-2194(1993).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-tyrosine = CO2 + tyramine; Xref=Rhea:RHEA:14345,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:58315,
CC         ChEBI:CHEBI:327995; EC=4.1.1.25;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000305}.
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DR   EMBL; M96069; AAA33859.1; -; mRNA.
DR   AlphaFoldDB; Q06085; -.
DR   SMR; Q06085; -.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0004837; F:tyrosine decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR010977; Aromatic_deC.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   InterPro; IPR021115; Pyridoxal-P_BS.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   PRINTS; PR00800; YHDCRBOXLASE.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   PROSITE; PS00392; DDC_GAD_HDC_YDC; 1.
PE   2: Evidence at transcript level;
KW   Decarboxylase; Lyase; Pyridoxal phosphate.
FT   CHAIN           <1..>432
FT                   /note="Tyrosine decarboxylase 1"
FT                   /id="PRO_0000146995"
FT   MOD_RES         294
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         432
SQ   SEQUENCE   432 AA;  48503 MW;  8F225DC39F3705AE CRC64;
     EFRRQGHLMI DFLADYYRKV ENYPVRSQVS PGYLREILPE SAPYNPESLE TILQDVQTKI
     IPGITHWQSP NFFAYFPSSG STAGFLGEML STGFNVVGFN WMVSPAATEL ENVVTDWFGK
     MLQLPKSFLF SGGGGGVLQG TTCEAILCTL VAARDKNLRQ HGMDNIGKLV VYCSDQTHSA
     LQKAAKIAGI DPKNFRAIET SKSSNFKLCP KRLESAILYD LQNGLIPLYL CATVGTTSST
     TVDPLPALTE VAKKYKLWVH VDAAYAGSAC ICPEFRQYLD GVENADSFSL NAHKWFLTTL
     DCCCLWVRDP SALIKSLSTY PEFLKNNASE TNKVVDYKDW QIMLSRRFRA LKLWFVLRSY
     GVGQLREFIR GHVGMAKYFE GLVGMDNRFE VVAPRLFSMV CFRIKPSAMI GKNDEDEVNE
     INRKLLESVN DS