TYE7_CANAL
ID TYE7_CANAL Reviewed; 269 AA.
AC Q5AL36; A0A1D8PFK6;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Carbohydrate metabolism regulator TYE7;
GN Name=TYE7; OrderedLocusNames=CAALFM_C113140CA;
GN ORFNames=CaO19.12407, CaO19.4941;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=12388749; DOI=10.1091/mbc.e02-05-0272;
RA Nantel A., Dignard D., Bachewich C., Harcus D., Marcil A., Bouin A.P.,
RA Sensen C.W., Hogues H., van het Hoog M., Gordon P., Rigby T., Benoit F.,
RA Tessier D.C., Thomas D.Y., Whiteway M.;
RT "Transcription profiling of Candida albicans cells undergoing the yeast-to-
RT hyphal transition.";
RL Mol. Biol. Cell 13:3452-3465(2002).
RN [5]
RP INDUCTION.
RX PubMed=15273122; DOI=10.1128/aac.48.8.3064-3079.2004;
RA Karababa M., Coste A.T., Rognon B., Bille J., Sanglard D.;
RT "Comparison of gene expression profiles of Candida albicans azole-resistant
RT clinical isolates and laboratory strains exposed to drugs inducing
RT multidrug transporters.";
RL Antimicrob. Agents Chemother. 48:3064-3079(2004).
RN [6]
RP INDUCTION.
RX PubMed=15201233; DOI=10.1093/jac/dkh336;
RA Barker K.S., Crisp S., Wiederhold N., Lewis R.E., Bareither B.,
RA Eckstein J., Barbuch R., Bard M., Rogers P.D.;
RT "Genome-wide expression profiling reveals genes associated with
RT amphotericin B and fluconazole resistance in experimentally induced
RT antifungal resistant isolates of Candida albicans.";
RL J. Antimicrob. Chemother. 54:376-385(2004).
RN [7]
RP INDUCTION.
RX PubMed=15917516; DOI=10.1128/aac.49.6.2226-2236.2005;
RA Liu T.T., Lee R.E., Barker K.S., Lee R.E., Wei L., Homayouni R.,
RA Rogers P.D.;
RT "Genome-wide expression profiling of the response to azole, polyene,
RT echinocandin, and pyrimidine antifungal agents in Candida albicans.";
RL Antimicrob. Agents Chemother. 49:2226-2236(2005).
RN [8]
RP INDUCTION.
RX PubMed=16002644; DOI=10.1128/ec.4.7.1175-1190.2005;
RA Zhao R., Daniels K.J., Lockhart S.R., Yeater K.M., Hoyer L.L., Soll D.R.;
RT "Unique aspects of gene expression during Candida albicans mating and
RT possible G(1) dependency.";
RL Eukaryot. Cell 4:1175-1190(2005).
RN [9]
RP INDUCTION.
RX PubMed=17605131; DOI=10.1002/yea.1514;
RA Sexton J.A., Brown V., Johnston M.;
RT "Regulation of sugar transport and metabolism by the Candida albicans Rgt1
RT transcriptional repressor.";
RL Yeast 24:847-860(2007).
RN [10]
RP FUNCTION, AND DNA-BINDING.
RX PubMed=19816560; DOI=10.1371/journal.ppat.1000612;
RA Askew C., Sellam A., Epp E., Hogues H., Mullick A., Nantel A., Whiteway M.;
RT "Transcriptional regulation of carbohydrate metabolism in the human
RT pathogen Candida albicans.";
RL PLoS Pathog. 5:E1000612-E1000612(2009).
RN [11]
RP FUNCTION.
RX PubMed=21414038; DOI=10.1111/j.1365-2958.2011.07626.x;
RA Bonhomme J., Chauvel M., Goyard S., Roux P., Rossignol T., d'Enfert C.;
RT "Contribution of the glycolytic flux and hypoxia adaptation to efficient
RT biofilm formation by Candida albicans.";
RL Mol. Microbiol. 80:995-1013(2011).
CC -!- FUNCTION: Key transcriptional regulator of carbohydrate metabolism.
CC Binds the promoter sequences of the glycolytic genes at the CANNTG
CC motif and activates their expression during growth on either
CC fermentable or non-fermentable carbon sources as well as under hypoxic
CC growth conditions. Complete glycolytic activation by GAL4 and TYE7 is
CC required for full virulence. Involved in biofilm formation and
CC negatively regulates hyphal formation under hypoxia. Controls also the
CC expression of the copper transport protein CTR1.
CC {ECO:0000269|PubMed:19816560, ECO:0000269|PubMed:21414038}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- INDUCTION: Expression is controlled by RTG1 and is down-regulated
CC during mating process, yeast-to-hyphal transition, and in presence of
CC benomyl, amphotericin B, and caspofungin. {ECO:0000269|PubMed:12388749,
CC ECO:0000269|PubMed:15201233, ECO:0000269|PubMed:15273122,
CC ECO:0000269|PubMed:15917516, ECO:0000269|PubMed:16002644,
CC ECO:0000269|PubMed:17605131}.
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DR EMBL; CP017623; AOW26923.1; -; Genomic_DNA.
DR RefSeq; XP_722152.1; XM_717059.1.
DR AlphaFoldDB; Q5AL36; -.
DR SMR; Q5AL36; -.
DR STRING; 237561.Q5AL36; -.
DR PRIDE; Q5AL36; -.
DR GeneID; 3636203; -.
DR KEGG; cal:CAALFM_C113140CA; -.
DR CGD; CAL0000180094; TYE7.
DR VEuPathDB; FungiDB:C1_13140C_A; -.
DR eggNOG; KOG2588; Eukaryota.
DR HOGENOM; CLU_067895_1_0_1; -.
DR InParanoid; Q5AL36; -.
DR OMA; SQKKAHN; -.
DR OrthoDB; 1574461at2759; -.
DR PHI-base; PHI:2865; -.
DR PRO; PR:Q5AL36; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:CGD.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:CGD.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0045991; P:carbon catabolite activation of transcription; IMP:CGD.
DR GO; GO:0071456; P:cellular response to hypoxia; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:1900429; P:negative regulation of filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:0045821; P:positive regulation of glycolytic process; IMP:CGD.
DR GO; GO:1900233; P:positive regulation of single-species biofilm formation on inanimate substrate; IMP:CGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:CGD.
DR GO; GO:0044011; P:single-species biofilm formation on inanimate substrate; IMP:CGD.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Carbohydrate metabolism; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Virulence.
FT CHAIN 1..269
FT /note="Carbohydrate metabolism regulator TYE7"
FT /id="PRO_0000422813"
FT DOMAIN 173..244
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 146..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..174
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 269 AA; 30525 MW; A59013640B69F505 CRC64;
MSSFQQENQL NANNNNNNVM NEYISYSVPL SPVTTNENPQ DYWMNGLIAN SVPISQTTSN
SDINYSQPPN PINFNSIFEG VNIFSNDDFT SSSNDISLAN SPETNATSDS IAQNLDEVKV
KLENHNQARL DALEFAFETK SILKEQPKIK QEPGTKAATK PKRRAPRKKL TESQKKAHNK
IEKRYRININ AKIAGIQKII PWVAFEKTAF ETGEENETEA EAKNNTRLNK SMILEKATEY
ILHLQKKEEE YMAENQKLRE QVIKLGGEI
