TYMOS_HUMAN
ID TYMOS_HUMAN Reviewed; 123 AA.
AC Q8TAI1; A8K1S1;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 2.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=TYMS opposite strand protein;
GN Name=TYMSOS; Synonyms=C18orf56;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-62.
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TAI1; O95273: CCNDBP1; NbExp=3; IntAct=EBI-742060, EBI-748961;
CC Q8TAI1; Q13643: FHL3; NbExp=3; IntAct=EBI-742060, EBI-741101;
CC Q8TAI1; Q5VWX1: KHDRBS2; NbExp=3; IntAct=EBI-742060, EBI-742808;
CC Q8TAI1; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-742060, EBI-10172150;
CC Q8TAI1; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-742060, EBI-10171774;
CC Q8TAI1; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-742060, EBI-10172052;
CC Q8TAI1; Q99750: MDFI; NbExp=4; IntAct=EBI-742060, EBI-724076;
CC -!- CAUTION: Product of a dubious CDS prediction. Overlap the TYMS locus in
CC the opposite strand. {ECO:0000305}.
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DR EMBL; AK289986; BAF82675.1; -; mRNA.
DR EMBL; AP001178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028301; AAH28301.1; -; mRNA.
DR RefSeq; NP_001012734.2; NM_001012716.2.
DR AlphaFoldDB; Q8TAI1; -.
DR BioGRID; 138970; 16.
DR IntAct; Q8TAI1; 8.
DR iPTMnet; Q8TAI1; -.
DR PhosphoSitePlus; Q8TAI1; -.
DR BioMuta; HGNC:29553; -.
DR DMDM; 294862427; -.
DR PaxDb; Q8TAI1; -.
DR PRIDE; Q8TAI1; -.
DR DNASU; 494514; -.
DR GeneID; 494514; -.
DR CTD; 494514; -.
DR DisGeNET; 494514; -.
DR GeneCards; TYMSOS; -.
DR HGNC; HGNC:29553; TYMSOS.
DR neXtProt; NX_Q8TAI1; -.
DR PharmGKB; PA134956204; -.
DR InParanoid; Q8TAI1; -.
DR PathwayCommons; Q8TAI1; -.
DR SignaLink; Q8TAI1; -.
DR BioGRID-ORCS; 494514; 4 hits in 175 CRISPR screens.
DR ChiTaRS; TYMSOS; human.
DR GenomeRNAi; 494514; -.
DR Pharos; Q8TAI1; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8TAI1; protein.
PE 5: Uncertain;
KW Reference proteome.
FT CHAIN 1..123
FT /note="TYMS opposite strand protein"
FT /id="PRO_0000286709"
FT REGION 57..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 62
FT /note="R -> G (in dbSNP:rs2853533)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032162"
SQ SEQUENCE 123 AA; 13402 MW; 8897DD5FFF08A090 CRC64;
MTPASGATAS LGRLRARPRS RWDAAYLPAV AAVCVARASH VPNGTLRFGV CKARRTMRPL
PRRIEVRTKR GPQRPAAPER SPQPRLPPSR HPSRRGPRRH LSGCSAPACR IPTGCRCPCG
RPS
