ID   TYPH1_CUPNH             Reviewed;         520 AA.
AC   Q0KA59;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Putative thymidine phosphorylase 1 {ECO:0000255|HAMAP-Rule:MF_00703};
DE            EC=2.4.2.4 {ECO:0000255|HAMAP-Rule:MF_00703};
DE   AltName: Full=TdRPase 1 {ECO:0000255|HAMAP-Rule:MF_00703};
GN   OrderedLocusNames=H16_A2012;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate +
CC         thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00703};
CC   -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC       phosphorylase family. Type 2 subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00703}.
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DR   EMBL; AM260479; CAJ93112.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0KA59; -.
DR   SMR; Q0KA59; -.
DR   STRING; 381666.H16_A2012; -.
DR   PRIDE; Q0KA59; -.
DR   EnsemblBacteria; CAJ93112; CAJ93112; H16_A2012.
DR   KEGG; reh:H16_A2012; -.
DR   eggNOG; COG0213; Bacteria.
DR   HOGENOM; CLU_025040_6_0_4; -.
DR   OMA; CSTHTDY; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro.
DR   GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR   GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1030.10; -; 1.
DR   Gene3D; 3.90.1170.30; -; 1.
DR   HAMAP; MF_00703; Thymid_phosp_2; 1.
DR   InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR   InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR   InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom_sf.
DR   InterPro; IPR035902; Nuc_phospho_transferase.
DR   InterPro; IPR036566; PYNP-like_C_sf.
DR   InterPro; IPR013102; PYNP_C.
DR   InterPro; IPR017872; Pyrmidine_PPase_CS.
DR   InterPro; IPR028579; Thym_Pase_Put.
DR   InterPro; IPR013466; Thymidine/AMP_Pase.
DR   InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR   PANTHER; PTHR10515; PTHR10515; 1.
DR   Pfam; PF02885; Glycos_trans_3N; 1.
DR   Pfam; PF00591; Glycos_transf_3; 1.
DR   Pfam; PF07831; PYNP_C; 1.
DR   SMART; SM00941; PYNP_C; 1.
DR   SUPFAM; SSF47648; SSF47648; 1.
DR   SUPFAM; SSF52418; SSF52418; 1.
DR   SUPFAM; SSF54680; SSF54680; 1.
DR   TIGRFAMs; TIGR02645; ARCH_P_rylase; 1.
DR   PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..520
FT                   /note="Putative thymidine phosphorylase 1"
FT                   /id="PRO_0000314708"
SQ   SEQUENCE   520 AA;  54581 MW;  4DA9BFC23FD5A27E CRC64;
     MNDASSDPGI PGRPGDVVAA AAPREVGALV FRPLEIDTWQ EHVIYMHPDC PVCRAEGFSA
     QARVRVQIGD RSLIATLTLL GAPLLNTGEA SLSLSAARTL SARAGDVVHV THAPALESVR
     ALRAKIYGCH LDSVQLDGII GDISAGRYAD VHIAAFLTAC ADGRMSLRET VDLTRAMVRS
     GQRLNWDREV VADKHCVGGL PGNRTTPVVV AIAAAAGLLL PKTSSRAITS PAGTADTMEA
     LTRVTLDSTE LRRVVEQVGA ALVWGGALSL SPADDVLIRV ERALDIDSDA QLVASILSKK
     IAAGSTHVLI DVPVGPTAKI REDSDLARLD LAMTKVADAF GLKLRILRTD GSQPVGRGVG
     PALEALDVLA VLQCQPTAPA DLRERSLLLA GELLEFCGAI PPGQGRLLAG SLLDSGAAWA
     RFQAICEAQG GLRTPGQAVF RRDVVAARSG IVTSVDNRHV ARTAKLAGAP RRQVAGLELH
     VRAGDEVVAG APLCTLHAQA SGELEYAFSY ALAHDPFRIE