ID   TYPH2_CUPPJ             Reviewed;         512 AA.
AC   Q46S32;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Putative thymidine phosphorylase 2 {ECO:0000255|HAMAP-Rule:MF_00703};
DE            EC=2.4.2.4 {ECO:0000255|HAMAP-Rule:MF_00703};
DE   AltName: Full=TdRPase 2 {ECO:0000255|HAMAP-Rule:MF_00703};
GN   OrderedLocusNames=Reut_B4704;
OS   Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
OS   (strain JMP 134)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=264198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JMP134 / LMG 1197;
RX   PubMed=20339589; DOI=10.1371/journal.pone.0009729;
RA   Lykidis A., Perez-Pantoja D., Ledger T., Mavromatis K., Anderson I.J.,
RA   Ivanova N.N., Hooper S.D., Lapidus A., Lucas S., Gonzalez B.,
RA   Kyrpides N.C.;
RT   "The complete multipartite genome sequence of Cupriavidus necator JMP134, a
RT   versatile pollutant degrader.";
RL   PLoS ONE 5:E9729-E9729(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate +
CC         thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00703};
CC   -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC       phosphorylase family. Type 2 subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00703}.
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DR   EMBL; CP000091; AAZ64052.1; -; Genomic_DNA.
DR   RefSeq; WP_011300818.1; NC_007348.1.
DR   AlphaFoldDB; Q46S32; -.
DR   SMR; Q46S32; -.
DR   STRING; 264198.Reut_B4704; -.
DR   EnsemblBacteria; AAZ64052; AAZ64052; Reut_B4704.
DR   KEGG; reu:Reut_B4704; -.
DR   eggNOG; COG0213; Bacteria.
DR   HOGENOM; CLU_025040_6_0_4; -.
DR   OMA; CSTHTDY; -.
DR   OrthoDB; 1724909at2; -.
DR   GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro.
DR   GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR   GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1030.10; -; 1.
DR   Gene3D; 3.90.1170.30; -; 1.
DR   HAMAP; MF_00703; Thymid_phosp_2; 1.
DR   InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR   InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR   InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom_sf.
DR   InterPro; IPR035902; Nuc_phospho_transferase.
DR   InterPro; IPR036566; PYNP-like_C_sf.
DR   InterPro; IPR013102; PYNP_C.
DR   InterPro; IPR017872; Pyrmidine_PPase_CS.
DR   InterPro; IPR028579; Thym_Pase_Put.
DR   InterPro; IPR013466; Thymidine/AMP_Pase.
DR   InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR   PANTHER; PTHR10515; PTHR10515; 1.
DR   Pfam; PF02885; Glycos_trans_3N; 1.
DR   Pfam; PF00591; Glycos_transf_3; 1.
DR   Pfam; PF07831; PYNP_C; 1.
DR   SMART; SM00941; PYNP_C; 1.
DR   SUPFAM; SSF47648; SSF47648; 1.
DR   SUPFAM; SSF52418; SSF52418; 1.
DR   SUPFAM; SSF54680; SSF54680; 1.
DR   TIGRFAMs; TIGR02645; ARCH_P_rylase; 1.
DR   PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Transferase.
FT   CHAIN           1..512
FT                   /note="Putative thymidine phosphorylase 2"
FT                   /id="PRO_0000314711"
SQ   SEQUENCE   512 AA;  53921 MW;  8CCDB5A89B7907E7 CRC64;
     MQANELKLAA GEGQGSEPLI FKPLGIDTWQ EHVIYLHPDC PVCRAEGFTA QARVQVRIGE
     ASLIATLNLV GAPLLDTGEA SLSASAAQAL EARAGDVVAI SHAPALESVR ALRAKIYGRR
     LDGAQIDSII SDISAGRYPD VYISAFLAAC ADGRMNRRET VDLTRAMVHS GERLSWSHAV
     VADKHCVGGL PGNRTTPIVV AIAAAGGLVL PKTSSRAITS PAGTADTMET LTRVALSAAE
     LRHVVERVGA SLVWGGALNL SPADDILIRV ERALDIDSDA QLVASILSKK VAAGSTHILI
     DVPVGPTAKV REDRDLERLE AAMRHVAGAF GLHILMVRTD GTQPLGRGIG PALEARDILA
     VLQRTVAAPP DLRERSVMLA GALLEFCGAA PRGAGEKAAG QLLDSGAAWR KFQAICEAQG
     GLRVPGEAIF RRDIVAPHAG KVIAIDNRHI ARTAKLAGAP MRQVAGLEMR VRVNDEVRAG
     QPLFTVHAQA SGELDYSCSY ALAHPAVSIE PH