ID   TYPH_BRADU              Reviewed;         513 AA.
AC   Q89QK7;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Putative thymidine phosphorylase {ECO:0000255|HAMAP-Rule:MF_00703};
DE            EC=2.4.2.4 {ECO:0000255|HAMAP-Rule:MF_00703};
DE   AltName: Full=TdRPase {ECO:0000255|HAMAP-Rule:MF_00703};
GN   OrderedLocusNames=bll3117;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate +
CC         thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00703};
CC   -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC       phosphorylase family. Type 2 subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00703}.
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DR   EMBL; BA000040; BAC48382.1; -; Genomic_DNA.
DR   RefSeq; NP_769757.1; NC_004463.1.
DR   RefSeq; WP_011085901.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q89QK7; -.
DR   SMR; Q89QK7; -.
DR   STRING; 224911.27351375; -.
DR   EnsemblBacteria; BAC48382; BAC48382; BAC48382.
DR   GeneID; 64022868; -.
DR   KEGG; bja:bll3117; -.
DR   PATRIC; fig|224911.44.peg.2747; -.
DR   eggNOG; COG0213; Bacteria.
DR   HOGENOM; CLU_025040_6_0_5; -.
DR   InParanoid; Q89QK7; -.
DR   OMA; QMVASIM; -.
DR   PhylomeDB; Q89QK7; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro.
DR   GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR   GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1030.10; -; 1.
DR   Gene3D; 3.90.1170.30; -; 1.
DR   HAMAP; MF_00703; Thymid_phosp_2; 1.
DR   InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR   InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR   InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom_sf.
DR   InterPro; IPR035902; Nuc_phospho_transferase.
DR   InterPro; IPR036566; PYNP-like_C_sf.
DR   InterPro; IPR013102; PYNP_C.
DR   InterPro; IPR017872; Pyrmidine_PPase_CS.
DR   InterPro; IPR028579; Thym_Pase_Put.
DR   InterPro; IPR013466; Thymidine/AMP_Pase.
DR   InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR   PANTHER; PTHR10515; PTHR10515; 1.
DR   Pfam; PF02885; Glycos_trans_3N; 1.
DR   Pfam; PF00591; Glycos_transf_3; 1.
DR   Pfam; PF07831; PYNP_C; 1.
DR   PIRSF; PIRSF000478; TP_PyNP; 1.
DR   SMART; SM00941; PYNP_C; 1.
DR   SUPFAM; SSF47648; SSF47648; 1.
DR   SUPFAM; SSF52418; SSF52418; 1.
DR   SUPFAM; SSF54680; SSF54680; 1.
DR   TIGRFAMs; TIGR02645; ARCH_P_rylase; 1.
DR   PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..513
FT                   /note="Putative thymidine phosphorylase"
FT                   /id="PRO_0000059094"
SQ   SEQUENCE   513 AA;  54664 MW;  9CB21EA3DB680722 CRC64;
     MHPDLPHSQL KIRRVRLDTG RENVVVISRQ SKALRAEIFR GFSRVELRLN GKVLLATLLI
     TDDDTLAAQD EIGLSEPAFR RFAEPVGTLV AVTPATPPES LEAVRAKIRG RTLSQAEIGA
     IINDLAHYRY SDMEIAAFLI GSASFITSDE LLALTGAMAQ AGTQLVWPDP VVVDKHCIGG
     IPGNRTSMVV VPIVAAHGLP IPKTSSRAIT SPAGTADTME VLARVNVGVE EMKAIVSSCN
     GCLIWGGHVN LSPADDVLIS VERPLSLDTR EQMVASIMSK KIAAGSTHLL IDIPVGPTAK
     VTGAVEAMRL RKLFEFVGDR FGRTVEVITT DGRQPIGNGI GPVLEANDVM AVLGNDKDAP
     RDLREKSLRL AAHLLEYDPK LRGGAGYARA RELLDSGAAL KQMQKIIDAQ GPSTCSTELG
     SLSFDIKAAH DGTVSAIDCL RLNRLARTAG APLDKGAGIR LFKKIGDHVE QGEPLYRVYA
     FDQPEHDLAA SAAAAGNGYA VDGHDALPSK TAS