ID   TYPH_LACRH              Reviewed;          23 AA.
AC   P19663;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Thymidine phosphorylase;
DE            EC=2.4.2.4;
DE   AltName: Full=TdRPase;
DE   Flags: Fragment;
GN   Name=deoA;
OS   Lacticaseibacillus rhamnosus (Lactobacillus rhamnosus).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=47715;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBUNIT.
RC   STRAIN=ATCC 7469 / DSM 20021 / JCM 1136 / CCUG 21452 / KCTC 1046 / NCDO 243
RC   / NCIMB 6375 / NCTC 12953;
RX   PubMed=2119230; DOI=10.1016/0167-4838(90)90089-x;
RA   Avraham Y., Grossowicz N., Yashphe J.;
RT   "Purification and characterization of uridine and thymidine phosphorylase
RT   from Lactobacillus casei.";
RL   Biochim. Biophys. Acta 1040:287-293(1990).
CC   -!- FUNCTION: The enzymes which catalyze the reversible phosphorolysis of
CC       pyrimidine nucleosides are involved in the degradation of these
CC       compounds and in their utilization as carbon and energy sources, or in
CC       the rescue of pyrimidine bases for nucleotide synthesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate +
CC         thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4;
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:2119230}.
CC   -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC       phosphorylase family. {ECO:0000305}.
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DR   PIR; S11384; S11384.
DR   AlphaFoldDB; P19663; -.
DR   STRING; 568703.LGG_00933; -.
DR   eggNOG; COG0057; Bacteria.
DR   GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycosyltransferase; Transferase.
FT   CHAIN           1..>23
FT                   /note="Thymidine phosphorylase"
FT                   /id="PRO_0000059077"
FT   NON_TER         23
SQ   SEQUENCE   23 AA;  2752 MW;  8705C9C4D82C1AD7 CRC64;
     MVKIGINEFG RIGRLAFRRI YEL