ID   TYPH_PSEU5              Reviewed;         526 AA.
AC   A4VHV6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Putative thymidine phosphorylase {ECO:0000255|HAMAP-Rule:MF_00703};
DE            EC=2.4.2.4 {ECO:0000255|HAMAP-Rule:MF_00703};
DE   AltName: Full=TdRPase {ECO:0000255|HAMAP-Rule:MF_00703};
GN   OrderedLocusNames=PST_0860;
OS   Pseudomonas stutzeri (strain A1501).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=379731;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A1501;
RX   PubMed=18495935; DOI=10.1073/pnas.0801093105;
RA   Yan Y., Yang J., Dou Y., Chen M., Ping S., Peng J., Lu W., Zhang W.,
RA   Yao Z., Li H., Liu W., He S., Geng L., Zhang X., Yang F., Yu H., Zhan Y.,
RA   Li D., Lin Z., Wang Y., Elmerich C., Lin M., Jin Q.;
RT   "Nitrogen fixation island and rhizosphere competence traits in the genome
RT   of root-associated Pseudomonas stutzeri A1501.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:7564-7569(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate +
CC         thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00703};
CC   -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC       phosphorylase family. Type 2 subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00703}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABP78557.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000304; ABP78557.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041755366.1; NC_009434.1.
DR   AlphaFoldDB; A4VHV6; -.
DR   SMR; A4VHV6; -.
DR   STRING; 379731.PST_0860; -.
DR   EnsemblBacteria; ABP78557; ABP78557; PST_0860.
DR   KEGG; psa:PST_0860; -.
DR   eggNOG; COG0213; Bacteria.
DR   HOGENOM; CLU_025040_6_0_6; -.
DR   Proteomes; UP000000233; Chromosome.
DR   GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro.
DR   GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR   GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1030.10; -; 1.
DR   Gene3D; 3.90.1170.30; -; 1.
DR   HAMAP; MF_00703; Thymid_phosp_2; 1.
DR   InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR   InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR   InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom_sf.
DR   InterPro; IPR035902; Nuc_phospho_transferase.
DR   InterPro; IPR036566; PYNP-like_C_sf.
DR   InterPro; IPR013102; PYNP_C.
DR   InterPro; IPR017872; Pyrmidine_PPase_CS.
DR   InterPro; IPR028579; Thym_Pase_Put.
DR   InterPro; IPR013466; Thymidine/AMP_Pase.
DR   InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR   PANTHER; PTHR10515; PTHR10515; 1.
DR   Pfam; PF02885; Glycos_trans_3N; 1.
DR   Pfam; PF00591; Glycos_transf_3; 1.
DR   Pfam; PF07831; PYNP_C; 1.
DR   SMART; SM00941; PYNP_C; 1.
DR   SUPFAM; SSF47648; SSF47648; 1.
DR   SUPFAM; SSF52418; SSF52418; 1.
DR   SUPFAM; SSF54680; SSF54680; 1.
DR   TIGRFAMs; TIGR02645; ARCH_P_rylase; 1.
DR   PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..526
FT                   /note="Putative thymidine phosphorylase"
FT                   /id="PRO_0000314707"
SQ   SEQUENCE   526 AA;  56665 MW;  8919244A6B4B3662 CRC64;
     MTSISSDTPL NGKAPVHLAL RRVAIDTYRE NVAYLHRDCA ACRAEGFQAL AKVEIRVNGR
     RILASLNLVD DPSIVGCDEL GLSEDAFAQL GAEAGVPAAI AQAEPAASIP ALHRKIAGER
     LNRDDFLAIM RDIAEHRYSK IELTAFVVAC NQGELDREEV FFLTDAMIRV GRRLDWREHP
     VVDKHCIGGI PGNRTSMLVV PIVAAHGMLC PKTSSRAITS PAGTADTMEV LANVELPFER
     LCEMVREERG CLAWGGSSDL SPADDVLIAV ERPLSIDSPG QMVASILSKK IAAGSTHLLL
     DIPIGPTAKV RSMAEAQRLR KLFEFVATRL GLTLDVVITD GRQPIGNGIG PVLEARDVIQ
     VLQNDPAAPI DLRQKALRLA GRMLEFDPDV RGGDGYAIAR DILDSGRALK KMRSIIAAQG
     GKPFDHNHPP LARLSFDVLA DCDAVVTGID NLQLARIARL AGAPKVQGAG VDILRKLGEP
     VRAGDCLYRV YADFPADLAF ARQATERASG VSLGSPEQVP TVFVEF