ID   TYRA_LACLA              Reviewed;         354 AA.
AC   Q9CET9;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Prephenate dehydrogenase;
DE            Short=PDH;
DE            EC=1.3.1.12;
GN   Name=tyrA; OrderedLocusNames=LL1745; ORFNames=L0058;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC         NADH; Xref=Rhea:RHEA:13869, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC         ChEBI:CHEBI:36242, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.12;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC       hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
CC   -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; AE005176; AAK05843.1; -; Genomic_DNA.
DR   PIR; A86843; A86843.
DR   RefSeq; NP_267901.1; NC_002662.1.
DR   RefSeq; WP_010906116.1; NC_002662.1.
DR   AlphaFoldDB; Q9CET9; -.
DR   SMR; Q9CET9; -.
DR   STRING; 272623.L0058; -.
DR   PaxDb; Q9CET9; -.
DR   EnsemblBacteria; AAK05843; AAK05843; L0058.
DR   KEGG; lla:L0058; -.
DR   PATRIC; fig|272623.7.peg.1871; -.
DR   eggNOG; COG0287; Bacteria.
DR   HOGENOM; CLU_055968_2_1_9; -.
DR   OMA; MWRDICL; -.
DR   UniPathway; UPA00122; UER00961.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003099; Prephen_DH.
DR   Pfam; PF02153; PDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; NAD;
KW   Oxidoreductase; Reference proteome; Tyrosine biosynthesis.
FT   CHAIN           1..354
FT                   /note="Prephenate dehydrogenase"
FT                   /id="PRO_0000119193"
FT   DOMAIN          2..283
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00522"
FT   DOMAIN          287..354
FT                   /note="ACT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
FT   BINDING         3..33
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   354 AA;  39496 MW;  766A20C932A627E2 CRC64;
     MKKILIIGLG LIGSSIALGI KRAHPDFEIL GSDRENIQEI AQKRGIIDSK VSLVEGAQKA
     DIIILAVPII TTLELLKKLA TLNLKKGLLI TDTGSTKSEI VELANQLFDE DKVRFIGGHP
     MAGSHKSGVM AADINLFENA YYVLTQENQE LRDLLKGLHA KFIILDAKEH DRVTGQVSHF
     PHILASALVW QSDDFSKEHP LVKHLAAGGF RDLTRIAEAD SLMWTSVLLS NPEITIDRIE
     NFKKQLDEIA LKIANKDSAA IEHFFEQGKK IRQAMEIHKG ALPNFYDLFI SVPDEKGVVL
     KVLGLLEDFS ITNVKINEEN REDIHGQLQI SFKRAEDLKE AREIIEKATD FTVV