TYRA_STAHJ
ID TYRA_STAHJ Reviewed; 363 AA.
AC Q4L672;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Prephenate dehydrogenase;
DE Short=PDH;
DE EC=1.3.1.12;
GN Name=tyrA; OrderedLocusNames=SH1544;
OS Staphylococcus haemolyticus (strain JCSC1435).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=279808;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCSC1435;
RX PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA Hiramatsu K.;
RT "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT extreme plasticity of its genome and the evolution of human-colonizing
RT staphylococcal species.";
RL J. Bacteriol. 187:7292-7308(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC NADH; Xref=Rhea:RHEA:13869, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC ChEBI:CHEBI:36242, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.12;
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
CC -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; AP006716; BAE04853.1; -; Genomic_DNA.
DR RefSeq; WP_011275835.1; NC_007168.1.
DR AlphaFoldDB; Q4L672; -.
DR SMR; Q4L672; -.
DR STRING; 279808.SH1544; -.
DR EnsemblBacteria; BAE04853; BAE04853; SH1544.
DR KEGG; sha:SH1544; -.
DR eggNOG; COG0287; Bacteria.
DR HOGENOM; CLU_055968_2_1_9; -.
DR OMA; MWRDICL; -.
DR OrthoDB; 533829at2; -.
DR UniPathway; UPA00122; UER00961.
DR Proteomes; UP000000543; Chromosome.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003099; Prephen_DH.
DR Pfam; PF02153; PDH; 1.
DR SUPFAM; SSF48179; SSF48179; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR SUPFAM; SSF55021; SSF55021; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; NAD;
KW Oxidoreductase; Tyrosine biosynthesis.
FT CHAIN 1..363
FT /note="Prephenate dehydrogenase"
FT /id="PRO_0000282665"
FT DOMAIN 2..291
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00522"
FT DOMAIN 296..363
FT /note="ACT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
FT BINDING 3..33
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255"
SQ SEQUENCE 363 AA; 40442 MW; 4E34B068A10921BC CRC64;
MKNILFIGLG LIGGSLASNL KYYQPNLTIS AFDADKDQLE KALSIGIIDK KIEDYSEGVK
NADIIIYATP VQQTELYLKE LPNYQTQSHL IVTDTGSTKS NIQSYEKFLL NNDIHLVGGH
PMAGSHKSGV LNSKKHLFEN AYYILVYDDA RNAESAKKLQ TLLSTTSAKF ITTSAQEHDY
VTGVVSHIPH IIASSLVHLS ETNSKNHTLV TQLAAGGFRD VTRIASSNAD MWRDITFSNQ
ENILHLLEML QQQLDSISSH IRLNDTNEVH SFFSGAKKFR DQLPVKQQGA LSIAYDLYVD
IPDKSGMISK VTSILSLHNI SISNLKILEI REDILGALQI SFKTPEDRER GIKALSDFET
YIL