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TYRP2_PIG
ID   TYRP2_PIG               Reviewed;         519 AA.
AC   Q4R1H1;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=L-dopachrome tautomerase;
DE            Short=DCT;
DE            Short=DT;
DE            EC=5.3.3.12;
DE   AltName: Full=L-dopachrome Delta-isomerase;
DE   AltName: Full=Tyrosinase-related protein 2;
DE            Short=TRP-2;
DE            Short=TRP2;
DE   Flags: Precursor;
GN   Name=DCT; Synonyms=TYRP2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RX   PubMed=16293128; DOI=10.1111/j.1365-2052.2005.01353.x;
RA   Okumura N., Hayashi T., Sekikawa H., Matsumoto T., Mikawa A., Hamasima N.,
RA   Awata T.;
RT   "Sequences and mapping of genes encoding porcine tyrosinase (TYR) and
RT   tyrosinase-related proteins (TYRP1 and TYRP2).";
RL   Anim. Genet. 36:513-516(2005).
CC   -!- FUNCTION: Plays a role in melanin biosynthesis. Catalyzes the
CC       conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid
CC       (DHICA). {ECO:0000250|UniProtKB:P40126}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate;
CC         Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509;
CC         EC=5.3.3.12; Evidence={ECO:0000250|UniProtKB:P29812};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000250|UniProtKB:P29812};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250|UniProtKB:P29812};
CC   -!- PATHWAY: Pigment biosynthesis; melanin biosynthesis.
CC   -!- SUBUNIT: Forms an OPN3-dependent complex with TYR in response to blue
CC       light in melanocytes. {ECO:0000250|UniProtKB:P40126}.
CC   -!- SUBCELLULAR LOCATION: Melanosome membrane
CC       {ECO:0000250|UniProtKB:P40126}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:P40126}. Melanosome
CC       {ECO:0000250|UniProtKB:P29812}. Note=Proper trafficking to melanosome
CC       is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
CC       {ECO:0000250|UniProtKB:P29812}.
CC   -!- PTM: Glycosylated. {ECO:0000250|UniProtKB:P29812}.
CC   -!- SIMILARITY: Belongs to the tyrosinase family. {ECO:0000305}.
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DR   EMBL; AB207241; BAD99582.1; -; mRNA.
DR   RefSeq; NP_001020398.1; NM_001025227.1.
DR   AlphaFoldDB; Q4R1H1; -.
DR   SMR; Q4R1H1; -.
DR   STRING; 9823.ENSSSCP00000010135; -.
DR   PaxDb; Q4R1H1; -.
DR   PeptideAtlas; Q4R1H1; -.
DR   PRIDE; Q4R1H1; -.
DR   Ensembl; ENSSSCT00000010405; ENSSSCP00000010135; ENSSSCG00000009490.
DR   GeneID; 574066; -.
DR   KEGG; ssc:574066; -.
DR   CTD; 1638; -.
DR   VGNC; VGNC:87192; DCT.
DR   eggNOG; ENOG502QRNA; Eukaryota.
DR   GeneTree; ENSGT00940000156856; -.
DR   HOGENOM; CLU_038693_1_0_1; -.
DR   InParanoid; Q4R1H1; -.
DR   OMA; RERWPRK; -.
DR   OrthoDB; 881347at2759; -.
DR   TreeFam; TF315865; -.
DR   Reactome; R-SSC-5662702; Melanin biosynthesis.
DR   UniPathway; UPA00785; -.
DR   Proteomes; UP000008227; Chromosome 11.
DR   Proteomes; UP000314985; Unplaced.
DR   Bgee; ENSSSCG00000009490; Expressed in oocyte and 28 other tissues.
DR   ExpressionAtlas; Q4R1H1; baseline.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042470; C:melanosome; ISS:UniProtKB.
DR   GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0004167; F:dopachrome isomerase activity; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0048468; P:cell development; IEA:Ensembl.
DR   GO; GO:0048066; P:developmental pigmentation; IBA:GO_Central.
DR   GO; GO:0006583; P:melanin biosynthetic process from tyrosine; ISS:UniProtKB.
DR   GO; GO:0002052; P:positive regulation of neuroblast proliferation; IBA:GO_Central.
DR   GO; GO:0009637; P:response to blue light; ISS:UniProtKB.
DR   GO; GO:0021847; P:ventricular zone neuroblast division; IBA:GO_Central.
DR   Gene3D; 1.10.1280.10; -; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; SSF48056; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Isomerase; Melanin biosynthesis; Membrane; Metal-binding;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix; Zinc.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..519
FT                   /note="L-dopachrome tautomerase"
FT                   /id="PRO_0000240477"
FT   TOPO_DOM        24..472
FT                   /note="Lumenal, melanosome"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        473..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        494..519
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   BINDING         189
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="A"
FT                   /evidence="ECO:0000250"
FT   BINDING         211
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="A"
FT                   /evidence="ECO:0000250"
FT   BINDING         220
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="A"
FT                   /evidence="ECO:0000250"
FT   BINDING         369
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="B"
FT                   /evidence="ECO:0000250"
FT   BINDING         373
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="B"
FT                   /evidence="ECO:0000250"
FT   BINDING         396
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="B"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        170
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        178
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        237
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        300
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        342
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        377
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   519 AA;  58573 MW;  E44F33A8D8CD2292 CRC64;
     MVPFRWGLLL GCLGSALGPG AQAQFPRVCM TVGSLQAKEC CPPLGAEPSN VCGSLEGRGR
     CAEVQADTRP WSGPYVLRNQ DDRERWPRKF FDRTCRCTGN FAGYNCGDCK FGWTGPNCDQ
     KKPLVVRQNI HSLTAQEREQ FLGALDLAKN TPHPDYVITT QHWLGLLGPN GTQPQIANCS
     IYDLFVWLHY YSVRDTLLGP GRPYKAIDFS HQGPAFVTWH RYHLLWLERA LQRLTGNESF
     AVPYWNFATG RNECDVCTDQ LLGAARPDDP TLISQNSRFS SWEIVCDSLD DYNRRVTLCN
     GTYEGLLRRN QVGRNSEKLP SLKDIEDCLS LKQFDNPPFF QNSTFSFRNA LEGFDKADGT
     LDSQVMSLHN LVHSFLNGTS ALPHSAANDP VFVVLHSFTD AIFDEWMKRF SPPVDAWPQE
     LAPIGHNRMY NMVPFFPPVT NEELFLTADQ LGYSYAIDLP VSVEGTPDWT TTLSVVMGML
     VVLVGLSALL LFLQYRRLRK GYTPLMETQL SHKRYTEEA
 
 
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