TYRPA_HAEIN
ID TYRPA_HAEIN Reviewed; 400 AA.
AC P44727;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Tyrosine-specific transport system 1 {ECO:0000250|UniProtKB:P0AAD4};
DE AltName: Full=Tyrosine permease 1 {ECO:0000250|UniProtKB:P0AAD4};
DE AltName: Full=Tyrosine:H(+) symporter 1 {ECO:0000250|UniProtKB:P0AAD4};
GN Name=tyrP-A; OrderedLocusNames=HI_0477;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Transports tyrosine across the cytoplasmic membrane. The
CC transport system is energized by the proton motive force.
CC {ECO:0000250|UniProtKB:P0AAD4}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + L-tyrosine(in) = H(+)(out) + L-tyrosine(out);
CC Xref=Rhea:RHEA:28875, ChEBI:CHEBI:15378, ChEBI:CHEBI:58315;
CC Evidence={ECO:0000250|UniProtKB:P0AAD4};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0AAD4}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Mtr/TnaB/TyrP permease subfamily. {ECO:0000305}.
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DR EMBL; L42023; AAC22135.1; -; Genomic_DNA.
DR PIR; B64071; B64071.
DR RefSeq; NP_438637.1; NC_000907.1.
DR RefSeq; WP_005693687.1; NC_000907.1.
DR AlphaFoldDB; P44727; -.
DR SMR; P44727; -.
DR STRING; 71421.HI_0477; -.
DR EnsemblBacteria; AAC22135; AAC22135; HI_0477.
DR KEGG; hin:HI_0477; -.
DR PATRIC; fig|71421.8.peg.496; -.
DR eggNOG; COG0814; Bacteria.
DR HOGENOM; CLU_038102_3_0_6; -.
DR OMA; PHIHQVN; -.
DR PhylomeDB; P44727; -.
DR BioCyc; HINF71421:G1GJ1-492-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0015173; F:aromatic amino acid transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR018227; Amino_acid_transport_2.
DR InterPro; IPR013061; Trp/try_permease_CS.
DR InterPro; IPR013059; Trp_tyr_transpt.
DR PANTHER; PTHR46997; PTHR46997; 1.
DR Pfam; PF03222; Trp_Tyr_perm; 1.
DR PRINTS; PR00166; AROAAPRMEASE.
DR TIGRFAMs; TIGR00837; araaP; 1.
DR PROSITE; PS00594; AROMATIC_AA_PERMEASE_1; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..400
FT /note="Tyrosine-specific transport system 1"
FT /id="PRO_0000093805"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 400 AA; 42759 MW; CA43D5335F0F3DE7 CRC64;
MNKTVGSTLL VAGTMIGAGM LAMPLTSAGI GFGFTLVLLL GLWALLTFSA LLFVELYQTA
ESDAGIGTLA EQYFGKTGRI IATAVLIIFL YALIAAYISG GGSLLKDLLP ESFGDKVSVL
LFTVIFGSFI VIGTHSVDKI NRVLFFVMLA AFAVVLSLML PEIKFDNLMA TPIDKALIIS
ASPVFFTAFG FHGSIPSLNK YLDGNVKALR FSILVGSAIT LCAYILWQLS THGLLTQNEF
LQILKEDATL NGLVKATFAI TGSNVIASAV KLFSTLALIT SFLGVGLGLL ECIEDLLKRS
FNVTAGRISL GLLTFIPPLV FALFYPEGFI LALGYAGQMF AFYAVVLPVS LVWKARRAHA
NLPYKVWGGN LTLIIVLVLG VLITSIPFAI RAGYLPFVVG
