ID   TYRPB_HAEIN             Reviewed;         406 AA.
AC   P44747;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Tyrosine-specific transport system 2 {ECO:0000250|UniProtKB:P0AAD4};
DE   AltName: Full=Tyrosine permease 2 {ECO:0000250|UniProtKB:P0AAD4};
DE   AltName: Full=Tyrosine:H(+) symporter 2 {ECO:0000250|UniProtKB:P0AAD4};
GN   Name=tyrP-B; OrderedLocusNames=HI_0528;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Transports tyrosine across the cytoplasmic membrane. The
CC       transport system is energized by the proton motive force.
CC       {ECO:0000250|UniProtKB:P0AAD4}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + L-tyrosine(in) = H(+)(out) + L-tyrosine(out);
CC         Xref=Rhea:RHEA:28875, ChEBI:CHEBI:15378, ChEBI:CHEBI:58315;
CC         Evidence={ECO:0000250|UniProtKB:P0AAD4};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0AAD4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       Mtr/TnaB/TyrP permease subfamily. {ECO:0000305}.
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DR   EMBL; L42023; AAC22185.1; -; Genomic_DNA.
DR   PIR; F64074; F64074.
DR   RefSeq; NP_438686.1; NC_000907.1.
DR   RefSeq; WP_010868997.1; NC_000907.1.
DR   AlphaFoldDB; P44747; -.
DR   SMR; P44747; -.
DR   STRING; 71421.HI_0528; -.
DR   EnsemblBacteria; AAC22185; AAC22185; HI_0528.
DR   KEGG; hin:HI_0528; -.
DR   PATRIC; fig|71421.8.peg.547; -.
DR   eggNOG; COG0814; Bacteria.
DR   HOGENOM; CLU_038102_3_0_6; -.
DR   OMA; LLCAFYC; -.
DR   PhylomeDB; P44747; -.
DR   BioCyc; HINF71421:G1GJ1-541-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0015173; F:aromatic amino acid transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018227; Amino_acid_transport_2.
DR   InterPro; IPR013061; Trp/try_permease_CS.
DR   InterPro; IPR013059; Trp_tyr_transpt.
DR   PANTHER; PTHR46997; PTHR46997; 1.
DR   Pfam; PF03222; Trp_Tyr_perm; 1.
DR   PRINTS; PR00166; AROAAPRMEASE.
DR   TIGRFAMs; TIGR00837; araaP; 1.
DR   PROSITE; PS00594; AROMATIC_AA_PERMEASE_1; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..406
FT                   /note="Tyrosine-specific transport system 2"
FT                   /id="PRO_0000093806"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   406 AA;  43476 MW;  F83D979FEA62D428 CRC64;
     MLKNKTFGSA LIIAGTTIGA GMLAMPLTSA GMGFGYTLLL LVGLWALLVY SGLLFVEVYQ
     TADQLDDGVA TLAEKYFGVP GRIFATLSLL VLLYALSAAY ITGGGSLLSG LPTAFGMEAM
     SLKTAIIIFT VVLGSFVVVG TKGVDGLTRV LFIGKLIAFA FVLFMMLPKV ATDNLMALPL
     DYAFVVSAAP IFLTSFGFHV IMASVNSYLG GSVDKFRRAI LIGTAIPLAA YLVWQLATHG
     VLSQSEFVRI LQADPTLNGL VNATREITGS HFMGEVVRVF SSLALITSFL GVMLGVFEGL
     GDLFKRYHLP NNRFVLTIAA FLPPLVFALF YPEGFITALS YAGLLCAFYC LILPISLAWR
     TRIENPTLPY RVAGGNFALV LALLIGVVIM LIPFLIQWGY LPVVAG