ID   TYRT_STRAT              Reviewed;         146 AA.
AC   P17687;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Tyrosinase cofactor;
DE   AltName: Full=ORF438;
DE   Flags: Precursor;
GN   Name=melC1;
OS   Streptomyces antibioticus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1890;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3932128; DOI=10.1016/0378-1119(85)90262-8;
RA   Bernan V., Filpula D., Herber W., Bibb M.J., Katz E.;
RT   "The nucleotide sequence of the tyrosinase gene from Streptomyces
RT   antibioticus and characterization of the gene product.";
RL   Gene 37:101-110(1985).
RN   [2]
RP   FUNCTION.
RX   PubMed=2840357; DOI=10.1016/0378-1119(88)90418-0;
RA   Lee Y.-H.W., Chen B.-F., Wu S.-Y., Leu W.-M., Lin J.-J., Chen C.C.,
RA   Lo S.J.;
RT   "A trans-acting gene is required for the phenotypic expression of a
RT   tyrosinase gene in Streptomyces.";
RL   Gene 65:71-81(1988).
CC   -!- FUNCTION: This protein may function to deliver copper to tyrosinase.
CC       {ECO:0000269|PubMed:2840357}.
CC   -!- PTM: Predicted to be exported by the Tat system. The position of the
CC       signal peptide cleavage has not been experimentally proven.
CC   -!- SIMILARITY: Belongs to the melC1 family. {ECO:0000305}.
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DR   EMBL; M11582; AAA88570.1; -; Genomic_DNA.
DR   PIR; A23971; A23971.
DR   AlphaFoldDB; P17687; -.
DR   SMR; P17687; -.
DR   STRING; 1890.AFM16_02905; -.
DR   PRIDE; P17687; -.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1880.10; -; 1.
DR   InterPro; IPR023199; GriE/MELC1_sf.
DR   InterPro; IPR010928; MelC1.
DR   InterPro; IPR006311; TAT_signal.
DR   Pfam; PF06236; MelC1; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   3: Inferred from homology;
KW   Copper; Melanin biosynthesis; Signal.
FT   SIGNAL          1..30
FT                   /note="Tat-type signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
FT   CHAIN           31..146
FT                   /note="Tyrosinase cofactor"
FT                   /id="PRO_0000065706"
FT   REGION          65..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   146 AA;  14883 MW;  E384D3CA11AC77AF CRC64;
     MPELTRRRAL GAAAVVAAGV PLVALPAARA DDRGHHTPEV PGNPAASGAP AAFDEIYKGR
     RIQGRTVTDG GGHHGGGHGG DGHGGGHHGG GYAVFVDGVE LHVMRNADGS WISVVSHYEP
     VDTPRAAARA AVDELQGARL LPFPSN