TYW31_THEKO
ID TYW31_THEKO Reviewed; 198 AA.
AC Q5JFK6;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 1 {ECO:0000255|HAMAP-Rule:MF_00266};
DE EC=2.1.1.282 {ECO:0000255|HAMAP-Rule:MF_00266};
DE AltName: Full=tRNA wyosine derivatives biosynthesis protein Taw3 1 {ECO:0000255|HAMAP-Rule:MF_00266};
GN Name=taw3-1 {ECO:0000255|HAMAP-Rule:MF_00266}; OrderedLocusNames=TK0175;
OS Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS (Pyrococcus kodakaraensis (strain KOD1)).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=69014;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX PubMed=15710748; DOI=10.1101/gr.3003105;
RA Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL Genome Res. 15:352-363(2005).
CC -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that acts
CC as a component of the wyosine derivatives biosynthesis pathway.
CC Probably methylates N-4 position of wybutosine-86 to produce
CC wybutosine-72. {ECO:0000255|HAMAP-Rule:MF_00266}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in
CC tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-
CC carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:36635, Rhea:RHEA-COMP:10378, Rhea:RHEA-
CC COMP:10379, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:73543, ChEBI:CHEBI:73550; EC=2.1.1.282;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00266};
CC -!- SIMILARITY: Belongs to the TYW3 family. {ECO:0000255|HAMAP-
CC Rule:MF_00266}.
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DR EMBL; AP006878; BAD84364.1; -; Genomic_DNA.
DR RefSeq; WP_011249130.1; NC_006624.1.
DR AlphaFoldDB; Q5JFK6; -.
DR SMR; Q5JFK6; -.
DR STRING; 69014.TK0175; -.
DR EnsemblBacteria; BAD84364; BAD84364; TK0175.
DR GeneID; 3234226; -.
DR KEGG; tko:TK0175; -.
DR PATRIC; fig|69014.16.peg.175; -.
DR eggNOG; arCOG04156; Archaea.
DR HOGENOM; CLU_047426_2_0_2; -.
DR InParanoid; Q5JFK6; -.
DR OMA; GKWHHYA; -.
DR OrthoDB; 118297at2157; -.
DR PhylomeDB; Q5JFK6; -.
DR Proteomes; UP000000536; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008175; F:tRNA methyltransferase activity; IBA:GO_Central.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR GO; GO:0031591; P:wybutosine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.1960.10; -; 1.
DR HAMAP; MF_00266; TYW3_archaea; 1.
DR InterPro; IPR022908; Taw3.
DR InterPro; IPR003827; tRNA_yW-synthesising.
DR InterPro; IPR036602; tRNA_yW-synthesising-like_sf.
DR Pfam; PF02676; TYW3; 1.
DR SUPFAM; SSF111278; SSF111278; 1.
PE 3: Inferred from homology;
KW Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW Transferase; tRNA processing.
FT CHAIN 1..198
FT /note="tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-
FT demethylwyosine(37)-N(4))-methyltransferase 1"
FT /id="PRO_0000157097"
SQ SEQUENCE 198 AA; 22932 MW; A232CBE8562688E6 CRC64;
MFLYTENFDE QKEKAMEGLR KALEEDKVDH DIIPLLEKIN ALQNYFTTSS CSGRISVMEM
PHFGDKVNSV WLGKWHREVR LEEVLEAVGK HRSGQLWFLV RSPILHVGAR TLEDAVRLLN
LAIGLGFKYS NIKSVSHKKL VVEIRSTERM DVPLGENGEL WVDEAYIEKI VNLANAQVRR
FKGKLKRLEE EIEKLQED
