ID   TYW3_METJA              Reviewed;         193 AA.
AC   Q58905;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase {ECO:0000255|HAMAP-Rule:MF_00266};
DE            EC=2.1.1.282 {ECO:0000255|HAMAP-Rule:MF_00266};
DE   AltName: Full=tRNA wyosine derivatives biosynthesis protein Taw3 {ECO:0000255|HAMAP-Rule:MF_00266};
GN   Name=taw3 {ECO:0000255|HAMAP-Rule:MF_00266}; OrderedLocusNames=MJ1510;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   GENE NAME.
RX   PubMed=20382657; DOI=10.1093/molbev/msq096;
RA   de Crecy-Lagard V., Brochier-Armanet C., Urbonavicius J., Fernandez B.,
RA   Phillips G., Lyons B., Noma A., Alvarez S., Droogmans L., Armengaud J.,
RA   Grosjean H.;
RT   "Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse
RT   pathway in Archaea.";
RL   Mol. Biol. Evol. 27:2062-2077(2010).
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that acts
CC       as a component of the wyosine derivatives biosynthesis pathway.
CC       Probably methylates N-4 position of wybutosine-86 to produce
CC       wybutosine-72. {ECO:0000255|HAMAP-Rule:MF_00266}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in
CC         tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-
CC         carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:36635, Rhea:RHEA-COMP:10378, Rhea:RHEA-
CC         COMP:10379, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:73543, ChEBI:CHEBI:73550; EC=2.1.1.282;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00266};
CC   -!- SIMILARITY: Belongs to the TYW3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00266}.
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DR   EMBL; L77117; AAB99529.1; -; Genomic_DNA.
DR   PIR; E64488; E64488.
DR   RefSeq; WP_010871033.1; NC_000909.1.
DR   AlphaFoldDB; Q58905; -.
DR   SMR; Q58905; -.
DR   STRING; 243232.MJ_1510; -.
DR   EnsemblBacteria; AAB99529; AAB99529; MJ_1510.
DR   GeneID; 1452417; -.
DR   KEGG; mja:MJ_1510; -.
DR   eggNOG; arCOG04156; Archaea.
DR   HOGENOM; CLU_047426_2_0_2; -.
DR   InParanoid; Q58905; -.
DR   OMA; GKWHHYA; -.
DR   OrthoDB; 118297at2157; -.
DR   PhylomeDB; Q58905; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008175; F:tRNA methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR   GO; GO:0031591; P:wybutosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1960.10; -; 1.
DR   HAMAP; MF_00266; TYW3_archaea; 1.
DR   InterPro; IPR022908; Taw3.
DR   InterPro; IPR003827; tRNA_yW-synthesising.
DR   InterPro; IPR036602; tRNA_yW-synthesising-like_sf.
DR   Pfam; PF02676; TYW3; 1.
DR   SUPFAM; SSF111278; SSF111278; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing.
FT   CHAIN           1..193
FT                   /note="tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-
FT                   demethylwyosine(37)-N(4))-methyltransferase"
FT                   /id="PRO_0000157093"
SQ   SEQUENCE   193 AA;  22401 MW;  D8E149EC7B4A51C9 CRC64;
     MGFLEDKKRT LMNLELAIRE GLVDEEIIPI LNKINEIDNY YTTSSCIGRV GIMEIPKDKN
     PKLYSRWLGK WHHYASYDEL FNALKNKKEG YIVFVMNSPI LHIACKDIES AKKMLELAIH
     SGLKASSIKS ISDKRVIVEI LTTYKVDTPI GEDGEIFVDN NYLKFLLDYS NSKLKRAREI
     LMRWANRLDE LKK