TYY2_MOUSE
ID TYY2_MOUSE Reviewed; 378 AA.
AC Q3TTC2; Q8CBG3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Transcription factor YY2;
DE AltName: Full=Yin and yang 2;
DE Short=YY-2;
GN Name=Yy2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Klar M., Dame C., Bode J.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=16377127; DOI=10.1016/j.ygeno.2005.11.001;
RA Luo C., Lu X., Stubbs L., Kim J.;
RT "Rapid evolution of a recently retroposed transcription factor YY2 in
RT mammalian genomes.";
RL Genomics 87:348-355(2006).
RN [4]
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=17478514; DOI=10.1093/nar/gkm235;
RA Kim J.D., Faulk C., Kim J.;
RT "Retroposition and evolution of the DNA-binding motifs of YY1, YY2 and
RT REX1.";
RL Nucleic Acids Res. 35:3442-3452(2007).
CC -!- FUNCTION: Functions as a multifunctional transcription factor that may
CC exhibit positive and negative control on a large number of genes. May
CC antagonize YY1 and function in development and differentiation.
CC {ECO:0000269|PubMed:17478514}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Weakly expressed by neuronal and glial cells in the
CC cerebral cortex. Expressed by Purkinje cells and in the granular layers
CC of the cerebellum. Expressed in all layers of spermatocytes in testis
CC but not detected in sperm cells. {ECO:0000269|PubMed:16377127}.
CC -!- MISCELLANEOUS: The gene encoding this protein appears to have arisen by
CC retrotransposition of the YY1 gene in placental mammals. It is encoded
CC by a single exon found in an intron of the gene Mbtps2.
CC -!- SIMILARITY: Belongs to the YY transcription factor family.
CC {ECO:0000305}.
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DR EMBL; EF688658; ABS18955.1; -; Genomic_DNA.
DR EMBL; AK036071; BAC29297.1; -; mRNA.
DR EMBL; AK161451; BAE36403.1; -; mRNA.
DR CCDS; CCDS53233.1; -.
DR RefSeq; NP_001092193.1; NM_001098723.1.
DR AlphaFoldDB; Q3TTC2; -.
DR SMR; Q3TTC2; -.
DR BioGRID; 791913; 4.
DR STRING; 10090.ENSMUSP00000070112; -.
DR iPTMnet; Q3TTC2; -.
DR PhosphoSitePlus; Q3TTC2; -.
DR jPOST; Q3TTC2; -.
DR MaxQB; Q3TTC2; -.
DR PaxDb; Q3TTC2; -.
DR PeptideAtlas; Q3TTC2; -.
DR PRIDE; Q3TTC2; -.
DR Antibodypedia; 483; 150 antibodies from 29 providers.
DR Ensembl; ENSMUST00000065806; ENSMUSP00000070112; ENSMUSG00000091736.
DR Ensembl; ENSMUST00000179062; ENSMUSP00000137233; ENSMUSG00000046873.
DR GeneID; 100073351; -.
DR KEGG; mmu:100073351; -.
DR UCSC; uc012hra.2; mouse.
DR CTD; 404281; -.
DR MGI; MGI:3837947; Yy2.
DR VEuPathDB; HostDB:ENSMUSG00000046873; -.
DR VEuPathDB; HostDB:ENSMUSG00000091736; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00510000048066; -.
DR GeneTree; ENSGT00940000154763; -.
DR HOGENOM; CLU_002678_42_2_1; -.
DR InParanoid; Q3TTC2; -.
DR OMA; PACERTF; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3TTC2; -.
DR TreeFam; TF106493; -.
DR BioGRID-ORCS; 100073351; 3 hits in 40 CRISPR screens.
DR PRO; PR:Q3TTC2; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q3TTC2; protein.
DR Bgee; ENSMUSG00000046873; Expressed in superior cervical ganglion and 222 other tissues.
DR ExpressionAtlas; Q3TTC2; baseline and differential.
DR Genevisible; Q3TTC2; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0031519; C:PcG protein complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:MGI.
DR InterPro; IPR017114; YY1-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR PIRSF; PIRSF037113; TF_Yin_yang; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..378
FT /note="Transcription factor YY2"
FT /id="PRO_0000323761"
FT ZN_FING 260..284
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 289..311
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 317..341
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 347..371
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 39..113
FT /note="Mediates transcriptional activation"
FT /evidence="ECO:0000250"
FT REGION 243..378
FT /note="Mediates transcriptional repression"
FT /evidence="ECO:0000250"
FT CONFLICT 327
FT /note="R -> H (in Ref. 2; BAC29297)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 378 AA; 42031 MW; 8B2E3C9BDFD0FC36 CRC64;
MASETEKLLC LNTESAEIPA DFVELLPPDN IGDIEAVSLE TSVGQTIEVY GDVGVDWAHG
SQYHSPVIAL QPLVGSSLSS RDHDKEMFVV QTREEEVVGY QDSDNLLFSP EFGSQMVLPV
NEDDYLQPTT ASFTGFLAAE NGQGELSPYE GNLCGLTTFI EAGAEESVNA DLGDKQWEQK
QIDGLDGEFP FTMWDDVNEK EDPIAEEQAG ESPPDYSEYM TGKKFPPEGI PGIDLSDPKQ
LAEFTSMRPK KPKGDFPRPI ACSHKGCEKM FKDNSAMRKH LHIHGPRVHV CAECGKAFVE
SSKLKRHQLV HTGEKPYQCT FEGCGRRFSL DFNLRTHVRI HTGDKPFVCP FDACNKKFAQ
STNLKSHILT HVKNKNDQ
