ID   TYY2_RATRT              Reviewed;         376 AA.
AC   Q2FAY8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Transcription factor YY2;
DE   AltName: Full=Yin and yang 2;
DE            Short=YY-2;
GN   Name=Yy2;
OS   Rattus rattus (Black rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16377127; DOI=10.1016/j.ygeno.2005.11.001;
RA   Luo C., Lu X., Stubbs L., Kim J.;
RT   "Rapid evolution of a recently retroposed transcription factor YY2 in
RT   mammalian genomes.";
RL   Genomics 87:348-355(2006).
CC   -!- FUNCTION: Functions as a multifunctional transcription factor that may
CC       exhibit positive and negative control on a large number of genes. May
CC       antagonize YY1 and function in development and differentiation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- MISCELLANEOUS: The gene encoding this protein appears to have arisen by
CC       retrotransposition of the YY1 gene in placental mammals. It is encoded
CC       by a single exon found in an intron of the gene Mbtps2.
CC   -!- SIMILARITY: Belongs to the YY transcription factor family.
CC       {ECO:0000305}.
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DR   EMBL; DQ107161; AAZ38710.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2FAY8; -.
DR   SMR; Q2FAY8; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR017114; YY1-like.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   PIRSF; PIRSF037113; TF_Yin_yang; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..376
FT                   /note="Transcription factor YY2"
FT                   /id="PRO_0000323762"
FT   ZN_FING         258..282
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         287..309
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         315..339
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         345..369
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          36..109
FT                   /note="Mediates transcriptional activation"
FT                   /evidence="ECO:0000250"
FT   REGION          201..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..376
FT                   /note="Mediates transcriptional repression"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   376 AA;  41792 MW;  C7FB8A535109201B CRC64;
     MASDTEKLMC LTTENAEIPA DFVELQPLDE IETVSLETNV SQTIEVYGDV GVDWAHGGHY
     HSPLIALQPL AGSNLSNGDH DQEMIIVQTR EEVVDYQDSD NLLLGTEFES QMVLPVTEDD
     YLQPTTATFS GFMAAENGQD ELSPYGGNLC GLTTIIEAGA EEGVNPDLGD KQWEQKQIQI
     DGLDGEFPFA MWEDNNLKED PVAEEEAGES TPDYSEYMTG KKFPPEGIPG IDLSDPKQLA
     EFTSMKPKKP KGDFPRPVAC SHKGCGKMFK DNSAMRKHLH IHGPRVHVCA ECGKAFVESS
     KLKRHQLVHT GEKPYQCTFE GCGRRFSLDF NLRTHVRIHT GDKPFVCPFD ACNKKFAQST
     NLKSHILTHV KNKNDQ