ID   TZ721_CYRSC             Reviewed;          93 AA.
AC   B3FIP1;
DT   11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=U8-theraphotoxin-Hs1a;
DE            Short=U8-TRTX-Hs1a;
DE   AltName: Full=HWTX-XVa1 {ECO:0000312|EMBL:ABY77688.1};
DE   Flags: Precursor;
OS   Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Cyriopagopus.
OX   NCBI_TaxID=29017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=18482741; DOI=10.1016/j.toxicon.2008.03.024;
RA   Jiang L., Peng L., Chen J., Zhang Y., Xiong X., Liang S.;
RT   "Molecular diversification based on analysis of expressed sequence tags
RT   from the venom glands of the Chinese bird spider Ornithoctonus huwena.";
RL   Toxicon 51:1479-1489(2008).
CC   -!- FUNCTION: Probable neurotoxin with ion channel impairing activity.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:18482741}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:18482741}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:A0A1D0C027}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 27 (Jztx-72) family. ICK-72
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EU195235; ABY77688.1; -; mRNA.
DR   AlphaFoldDB; B3FIP1; -.
DR   SMR; B3FIP1; -.
DR   ArachnoServer; AS000461; U8-theraphotoxin-Hs1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR035311; Cys_Knot_tox.
DR   Pfam; PF17486; Cys_Knot_tox; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..93
FT                   /note="U8-theraphotoxin-Hs1a"
FT                   /id="PRO_0000434617"
FT   DISULFID        40..81
FT                   /evidence="ECO:0000250|UniProtKB:A0A1D0C027"
FT   DISULFID        40..54
FT                   /evidence="ECO:0000250|UniProtKB:A0A1D0C027"
FT   DISULFID        53..66
FT                   /evidence="ECO:0000250|UniProtKB:A0A1D0C027"
FT   DISULFID        84..91
FT                   /evidence="ECO:0000250|UniProtKB:A0A1D0C027"
SQ   SEQUENCE   93 AA;  10675 MW;  56AE984B7BF79B56 CRC64;
     MKAILLLAIF SVLTVAICGV SQNYGNVRYN YTELPNGEYC YIPRRRCVTT EQCCKPYDTV
     NNFAACGMAW PEDKKRKVNE CYICDNELTL CTR