ID   TZ72_CHIGU              Reviewed;          93 AA.
AC   B1P1J5;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=U36-theraphotoxin-Cg1a;
DE            Short=U36-TRTX-Cg1a;
DE   AltName: Full=Jingzhaotoxin-72 {ECO:0000303|PubMed:18581053};
DE            Short=JZTX-72 {ECO:0000303|PubMed:18581053};
DE   Flags: Precursor;
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18581053; DOI=10.1007/s00018-008-8135-x;
RA   Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.;
RT   "Molecular diversity and evolution of cystine knot toxins of the tarantula
RT   Chilobrachys jingzhao.";
RL   Cell. Mol. Life Sci. 65:2431-2444(2008).
CC   -!- FUNCTION: Probable neurotoxin with ion channel impairing activity.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:18581053}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:18581053}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:A0A1D0C027}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 27 (Jztx-72) family. ICK-72
CC       subfamily. {ECO:0000305}.
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DR   EMBL; EU233926; ABY71745.1; -; mRNA.
DR   AlphaFoldDB; B1P1J5; -.
DR   SMR; B1P1J5; -.
DR   ArachnoServer; AS000873; U36-theraphotoxin-Cg1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR035311; Cys_Knot_tox.
DR   Pfam; PF17486; Cys_Knot_tox; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..93
FT                   /note="U36-theraphotoxin-Cg1a"
FT                   /id="PRO_0000398555"
FT   DISULFID        40..81
FT                   /evidence="ECO:0000250|UniProtKB:A0A1D0C027"
FT   DISULFID        40..54
FT                   /evidence="ECO:0000250|UniProtKB:A0A1D0C027"
FT   DISULFID        53..66
FT                   /evidence="ECO:0000250|UniProtKB:A0A1D0C027"
FT   DISULFID        84..91
FT                   /evidence="ECO:0000250|UniProtKB:A0A1D0C027"
SQ   SEQUENCE   93 AA;  10766 MW;  E7A11D2FCFA74193 CRC64;
     MKTVLHIAIF SAVVVAICGV RQNYGNVRYN YTELPNGEYC YIPRRRCDTT EQCCKPYDTI
     NNFAACGKAW PEDKKRKVNK CYICDNELTL CTR