U119B_DANRE
ID U119B_DANRE Reviewed; 243 AA.
AC Q90Z08; A9C3N9; B3DG53; Q502S5;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein unc-119 homolog B;
DE AltName: Full=Protein unc-119 homolog 1;
GN Name=unc119b; Synonyms=unc119, unc119.1, unc119c; ORFNames=si:dkey-117k10;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15593328; DOI=10.1002/gene.20089;
RA Manning A.G., Crawford B.D., Waskiewicz A.J., Pilgrim D.B.;
RT "unc-119 homolog required for normal development of the zebrafish nervous
RT system.";
RL Genesis 40:223-230(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION.
RX PubMed=22085962; DOI=10.1101/gad.173443.111;
RA Wright K.J., Baye L.M., Olivier-Mason A., Mukhopadhyay S., Sang L.,
RA Kwong M., Wang W., Pretorius P.R., Sheffield V.C., Sengupta P.,
RA Slusarski D.C., Jackson P.K.;
RT "An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary
RT cilium.";
RL Genes Dev. 25:2347-2360(2011).
CC -!- FUNCTION: Myristoyl-binding protein that acts as a cargo adapter:
CC specifically binds the myristoyl moiety of a subset of N-terminally
CC myristoylated proteins and is required for their localization. Plays a
CC key role in localization of proteins to the primary cilium membrane.
CC {ECO:0000269|PubMed:22085962}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Detected in embryo. Detected in larvae four days
CC after fertilization, in retina and neural tissues (at protein level).
CC Detected in embryos at the sphere stage, during gastrulation,
CC somitogenesis and in swimming larvae, both within and outside of the
CC developing nervous system. Detected in adults.
CC {ECO:0000269|PubMed:15593328}.
CC -!- DOMAIN: Adopts an immunoglobulin-like beta-sandwich fold forming a
CC hydrophobic cavity that capture N-terminally myristoylated target
CC peptides. Phe residues within the hydrophobic beta sandwich are
CC required for myristate binding (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PDE6D/unc-119 family. {ECO:0000305}.
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DR EMBL; AF387342; AAK70467.1; -; mRNA.
DR EMBL; CR376731; CAP19581.1; -; Genomic_DNA.
DR EMBL; BC162277; AAI62277.1; -; mRNA.
DR EMBL; BC162287; AAI62287.1; -; mRNA.
DR RefSeq; NP_997952.1; NM_212787.1.
DR AlphaFoldDB; Q90Z08; -.
DR SMR; Q90Z08; -.
DR STRING; 7955.ENSDARP00000011779; -.
DR PaxDb; Q90Z08; -.
DR Ensembl; ENSDART00000019907; ENSDARP00000011779; ENSDARG00000009629.
DR GeneID; 338230; -.
DR KEGG; dre:338230; -.
DR CTD; 338230; -.
DR ZFIN; ZDB-GENE-030219-130; unc119.1.
DR eggNOG; KOG4037; Eukaryota.
DR GeneTree; ENSGT00390000014595; -.
DR HOGENOM; CLU_088825_0_0_1; -.
DR InParanoid; Q90Z08; -.
DR OMA; IAKPPHC; -.
DR OrthoDB; 1270912at2759; -.
DR PhylomeDB; Q90Z08; -.
DR TreeFam; TF314474; -.
DR Reactome; R-DRE-5624138; Trafficking of myristoylated proteins to the cilium.
DR PRO; PR:Q90Z08; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000009629; Expressed in early embryo and 33 other tissues.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR GO; GO:0070121; P:Kupffer's vesicle development; IMP:ZFIN.
DR GO; GO:0042953; P:lipoprotein transport; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IMP:ZFIN.
DR Gene3D; 2.70.50.40; -; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR008015; PDED_dom.
DR InterPro; IPR037036; PDED_dom_sf.
DR Pfam; PF05351; GMP_PDE_delta; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Lipid-binding;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..243
FT /note="Protein unc-119 homolog B"
FT /id="PRO_0000337230"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 134
FT /ligand="tetradecanoate"
FT /ligand_id="ChEBI:CHEBI:30807"
FT /evidence="ECO:0000250"
FT CONFLICT 27
FT /note="H -> R (in Ref. 1; AAK70467 and 3; AAI62277/
FT AAI62287)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 243 AA; 28009 MW; AB234BB62F5000CA CRC64;
MNSQSSRNET AATAVNGSDS AAASRDHKSG GGVLKRLKSR RNQVDRRPVT EEELRALGRD
ITPDEVLGLR AVARDYLCKL EDNIYNIDFT RFKIRDLETG TVLFEIAKPP HCDLDEEDDE
NRDADTSAGR FVRYQFTPAF LKLRTVGATV EFTVGDQPVT NFRMIERHYF QDRLLKSFDF
DFGFCIPNSR NTCEHIYEFP QLPEDLIRLM IEHPYETRSD SFYFVDNKLI MHNKADYAYN
GGQ
